mistral92
Forum Senior
Topics: 4
Posts: 185
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i think that with intravenous infusion we assume that the rate of entry of drug in the body is constant the majority of drugs are FIRST ORDER
that is a constant fraction is cleared per unit of time ...therefore the rate of excretion of the drug would be proportional to it's concentration as the plasma drug concentration increases...
the diffrence with oral administerd drugs is there ABSORPTION so the plasma concentration of drugs would be proprtional by BOTH the RATE OF ABSORPTION and the rate of drug elimination.absorption of drugs adminitered by this route ( oral) is "'slowly".
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| peekay
Forum Guru
Topics: 102
Posts: 588
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it makes more sense after youe explanation.thank you mistral92
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| bobby
Forum Guru
Topics: 136
Posts: 569
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I will like to sumarize mitral92's concept in few words.
in IV, the bioavailability is 1 (100% drug absorbtion)
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| Quinn
Forum Elite
Topics: 63
Posts: 308
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Nice discussion...I agree with bobby, but it was great to hear mitral92's explaination 8)
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