hHey friends, please clear some doubts

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hHey friends, please clear some doubts

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sfk
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11/20/07 - 07:23 PM

I have come across a few discrepancies between goljan and UW.

1) whats the most common site for cancers in colon? UW- ascending colon, papi- sigmoid.

2)Role of desmopressin in vWF deficiency? UW- releases factor VIII from endothelium. goljan- increase synthesis.

3) Pathophys of Janeway lesions? UW- embolism, goljan- immune complex vasculitis.

Whom to trust. I think BIG DADDY_ ROBBINS, but i dont have it at hand right now.

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keepgoing
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11/20/07 - 11:46 PM

trust papi ! will check robbins for u.
gl!

Edited by keepgoing on 11/21/07 - 01:58 AM

new_n_lost
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11/21/07 - 01:23 AM

2)Role of desmopressin in vWF deficiency? UW- releases factor VIII from endothelium. goljan- increase synthesis.
It has yet to proved that where Factor VIII is stored or synthesized. But Desmopressin does help in inducing its secretion. ref.Emedicine and NEJM.

I will be looking for the rest of them.

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new_n_lost
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11/21/07 - 03:26 AM

3) Pathophys of Janeway lesions? UW- embolism, goljan- immune complex vasculitis.
In this case both r correct but Goljan has put it in clear words. By embolism UW went with initial theory that Janeway lesions are septic micro emboli and due to this presumption it was assumed that the actual organism can be culture but it was found on rare occasions. Recently it has been suggested that there is a possiblity that both Osler nodes and Janeway lesions are infact nothing but the deposition of the immune complexes alongside the vessel walls

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silver
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11/21/07 - 10:24 AM

i'm getting an error opening this file

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sfk
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11/21/07 - 11:42 AM

new_n_lost wrote:
2)Role of desmopressin in vWF deficiency? UW- releases factor VIII from endothelium. goljan- increase synthesis. It has yet to proved that where Factor VIII is stored or synthesized. But Desmopressin does help in inducing its secretion. ref.Emedicine and NEJM.

"inducing its secretion"? does that mean release??
Also, i'm not able to open the file, some error.
hey, keepgoing, please keep looking grin

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new_n_lost
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11/21/07 - 02:21 PM

I have re attached it again.

Attached Files:
Osler nodes and Janeway lesions.pdf (1154 KB, 9 downloads)

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sfk
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11/23/07 - 11:16 AM

nnl, i appreciate ur help, but thats a 1976 article, things must have surely cleared up by now.
any refence textbooks or something. i dont think i'm asking very tough questions. we can face such q's in the exam..........

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SmokyWaters
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11/25/07 - 04:08 AM

1) whats the most common site for cancers in colon? UW- ascending colon, papi- sigmoid.
SIGMOID is the most common portion of colorectal ca

2)Role of desmopressin in vWF deficiency? UW- releases factor VIII from endothelium. goljan- increase synthesis.

UW is rite

3) Pathophys of Janeway lesions? UW- embolism, goljan- immune complex vasculitis.

immune complex like osler nodes etc ... roth spots n splinter hemorrhages are ...embolic phenomenon
for reference... MEDSTUDY

Edited by SmokyWaters on 11/25/07 - 04:15 AM

sfk
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11/25/07 - 09:30 PM

#10

thanks a lot smokywaters. one question still remains.

SmokyWaters wrote:

immune complex like osler nodes etc ... roth spots n splinter hemorrhages are ...embolic phenomenon
for reference... MEDSTUDY

that doesnt tell anything about janeway lesions.

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SmokyWaters
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12/04/07 - 05:16 AM

#11

oooooopsies...sorry I missed that...2 are embolic and 2 are immune complex..
janeway is immune complex grin

hehe..sorry buddy

SmokyWaters
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12/04/07 - 05:16 AM

#12

that means papi is righttt... grin

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