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Kaplan Qbank USMLE



Author13 Posts
  #1

vitamin-B2=riboflavin

---component of GLUTHIONE REDUCTASE in pentose phosphate shunt=produces reduced glutathione.



glutathine reductase
pentose phosphste shunt-------------------------->reduced glutathione
B2
(RIBOFLAVIN)

  #2

NAD+---------->NADH2 REACTIONS

1.glyceraldehyde 3 phosphate-------->1,3 diphosphoglycerate (GLYCOLYSIS )

2.lactate ------->pyruvate (GLUCONEOGENESIS)

3.pyruvate ----------->acetyl co A (OXIDATIVE DECARBOXYLATION)

4.malate ---------->oxaloacetate (GLUCONEOGENESIS)

5.B-oxidation of fatty acids

  #3

NADH---------->NAD+ REACTIONS

1.DHAP------------------->glycerol 3 phosphate (VLDL SYNTHESIS)

2.acetoacetate---------------->B hydroxy butyurate (KETONE SYNTHESIS)


  #4

NADP+------------->?NADPH REACTIONS

1.glucose 6 phosphate --------------->6 phosphogluconate (PENTOSE PHOSPHATE
PATHWAY)

2.malate ------------>pyruvate (FATTY ACID SYNTHESIS)

  #5

BUZZWORDS

1.goats milk-------------------------------->deficient in vitamin B6
(PYRIDOXINE DEFICIENCY)

2.biotin deficiency---------------> alopecia

3.B2 (riboflavin)deficiency---------------->corneal neovascularization
--magenta coloured tongue

4. pantothenic acid (B5)-------->component of fatty acid synthase

  #6

Goats milk -------is low in FOLATE, B6,IRON compared to cows milk.

  #7

COFACTORS

1.selenium-------Is Good.
Is-------iodinase (converts t4 to t3 peripherally)
Good----Glutathione peroxidase

2.Manganese-
Man
Gane -----------------------Glycosyl transferases
Se -----------------------Superoxide dismutase

3.Molybdenum's X factor

Xanthine oxidase (uri acid synthesis in purine metabolism)

  #8

COFACTOR= ZINC

"Zinc is the Super Car Of American College Association"

Super=superoxide dismutase
Car=carbonic anhydrase
American=alkaline phosphatase
College=collagenes
Association=alcohol dehydrogenase

  #9

Zinc deficiency-----1. Dysguesia=decreased taste sensation
2.Poor wound healing
3.Rash aroud eyes /mouth
4.Hypogonadism

Seleium deficiency--------1. Muscle pain/weakness
2.Cardiomyopathy

  #10

Decreased synthesis of vitamin K dependent factors=hemorrhagic diathesis

is seen in -----------

1.vit K def
2.vitamin E toxicity
3.Manganese deficiency

  #11

APOLIPOPROTEINS


A-1 = activates LCAT enzyme
B 100 = binds to LDL recepter ,mediates VLDL seretion
C-2 = Cofactor for lipoprotein lipase
B 48 = Mediates chylomicron secretion
E = mediates Extra (remnant) uptake.

  #12

Acute intermittent porphyria-------->Uroporphyriogen 1 synthase def.


Porphyria cutanea tarda------------>Uroporphyriogen DECARBOXYLASE deficiency.

  #13

BLOTS

SNoW = DRoP

Southern=Dna
Northern=Rna
Western=Proteins







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