imnalini
Forum Senior
Topics: 10
Posts: 127
|
MOA
1.Abciximab-----------Monoclonal antibody
Binds to GP IIb/IIIa receptors on platelets
Inhibit platelet aggregation
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
HERPES VIRUS 8 --------KAPOSIS SARCOMA -------------Rx -----ALPHA INTERFERON
PACLITAXEL ---------Rx OF OVARIAN CANCER
REMEMBER-------
PACLITAXEL --------
1. M PHASE SPECIFIC
2.BIND TO TUBULIN
3.HYPERSTABILIZE POLYMERIZED MICROTUBULES
4.INHIBIT MITOTIC SPINDLE BRAEKAGE
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
HYDROXYUREA--------
1.INHIBIT RIBONUCLEOTIDE REDUCTASE
2.NO CONVERSION OF RIBONUCLEOTIDES TO DEOXYRIBONUCLEOTIDES
3.Rx OF CML
4. INCREASE HbF synthesis
5.crosses blood brain barrier
6. leucopenia and GI toxicity
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
2 CHLORODEOXYADENOSINE-------------
1. RESIST DEGRADATION BY ADENOSINE DEAMINASE
2.Rx OF HAIRY CELL LEUKEMIA
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
CYTARABINE--------
1.BLOCKS BOTH DNA AND RNA
2.S PHASE SPECIFIC
3. CEREBELLAR ATAXIA /HEPATITIS /PANCREATITIS
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
5 - FLUOROURACIL ------------
1.INHIBIT THYMIDYLATE SYNTHASE
2.EFFECTIVE THROUGHOUT CELL CYCLE
3. MUCOSITIS
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
6 MERCAPTOPURINE---------
1.INHIBIT PURINE SYNTHESIS
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
methotrexate---------> decrease dTMP ----->decrease DNA n protein synthesis
S/E-----macrovesicular fatty change in liver
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
5 fluorouracil--------
bioactivated to 5 F dUMP--------> COVALENTLY COMPLEXES FOLIC ACID-------> complex inhibits thymidylate synthase-------->decrased dTMP---------->decreased DNA n protein synthesis
uses=colon ca, solid tumors, basal cell ca (topical)
S/E------>photosensitivity
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
6 mercaptopurine-------------
uses= leukemia , lymphoma ( not CLL or hodgkins)
S/E ----->GI ,liver , bone marrow
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
CYTARABINE---------
S/E----->LEUCOPENIA , THROMBOCYTOPENIA , MEAGALOBLASTIC ANAEMIA
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
CYCLOPHOSPHAMIDE-----------
Require bioactivation by liver
uses= ovarian/breast ca , non hodgkins lymphoma , immunosuppressants
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
nitrosoureas------>MUSTINE'S and streptozocin
alkylate DNA
require bioactivation like cyclophosphamide
cross blood brain barrier----->CNS
uses----CNS tumours
S/E-----------CNS toxicity (dizziness , ataxia)
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
CISPLATIN AND CARBOPLATIN---------
ACT LIKE ALKYLATING AGENT
uses = testicular/ovarian ca , bladder ca , lung ca
S/E -nephrotoxicity , acoustic nerve damage
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
doixorubicin (adriamycin) ,daunorubicin------------
S/E----ALOPECIA , TOXIC EXTRAVASATION
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
ETOPOSIDE----------
G2 phase specific
S/E----alopecia , GI irritation
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
TRASTUZUMAB (HERCEPTIN)-------
MONOCLONAL ANTIBODY AGAINST HER2/erbB2
S/E----CARDIOTOXICITY
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
IMATINIB (GLEEVEC)----------
Philadelphia chromosome bcr-abl tyrosine kinase inhibitor
uses= CML , GI stromal tumors
S/E----- FLUID RETENTION
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
PACLITAXEL----------
ANAPHASE CANNOT OCCUR
S/E-------HYPERSENSITIVITY
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
1.Cyclophosphamide
2.Cisplatin/Carboplatin
3.busulphan
4.nitrosoureas
AREA LKYLATING AGENTS.
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
penicillin--------inhibit TRANSPEPTIDASE
NONCOMPETITIVE inhibition
S/E----1.hypersensitivity vasculitis=polyarteritis nodosa
2.warm autoimmune hemolytic anaemia=type 2
3.acute iterstitial nephritis=type 4 hypersensitivity
|
| imnalini
Forum Senior
Topics: 10
Posts: 127
|
oil of wintergreen =high conc of aspirin
|
| sidiyaa
Forum Newbie
Topics: 0
Posts: 39
|
thankx
|
|
| |
| | | | | | | | | | | | | | | | | | | | | | | |
