imnalini
Forum Senior
Topics: 10
Posts: 127
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HERBAL AGENTS USES
1echinacea--------------common cold
2feverfew----------------migraine
3ginkgo-------------------intermiottent claudication
4milk thistle--------------viral hepatitis
5kava-------------------chroic anxiety
6st. johns wort-----------depression
7saw palmetto--------------benign prostate hyperplasia
8melatonin----------------jet lag , insomnia
9DHEA------------------SLE,AIDS
(for symptoic improvement in females)
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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p450 INDUCERS--------
" Queen Barb takes Phen-phen and Refuses Greasy CarbS"
Q=quinidine
B=barbiturates
P= phenytoin
R=rifampicin
G= griseofulvin
C=carbamazepine
S=st jonns wort
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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P450 INHIITORS---------
"Inhibitors Stop Cyber-Kids from Eating Ggrapefruit"
I=isoiazid
S=sulphonamides
C=cimetidine
K=ketoconazole
E=Erythromycin
G=grape fruit juice
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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IN EUKARYOTES
RNA polymerase 1 makes--------->r RNA
RNA polymerase 2 makes---------->m RNA
RNA polymerase 3 makes--------->t RNA
IN PROKARYOTES
RNA polyerase (complex) makes all 3 kinds of RNA
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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Death cap mushroom -----contain alpha AMNITIN-----inhibits RNA polymerase 2.
RNA polymerase 2 ------opens DNA at promoter ste
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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MOA
Acyclovir==inhiit viral DNA polymerase when phosphorylated by viral thymidine kinase
Gancyclovir=inhibit CMV DNA polymerase when phosphorylated by CMV thymiodie kinase
Foscarnet= inhibits viral DNA polymerase BY BINDING TO PYROPHOSPHATE BINDING SITE OF ENZYME.(Does not require viral activation)
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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MOA
Ribavarin=
inhibit GUANINE nucleotide synthesis
by competitively inhibiting IMP Dehydrogenase.
Zanamivir, Oseltamivir=
Inhibit influenza NEURAMINIDASE
Terbinafine=
Inhibnits fungal enzyme SQUALENE EPOXIDE
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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MOA
AZOLES=
Inhibit fungal Ergosterol synthesis
Nystatin=
Binds to Ergosterol ,disrupting fungal membrane
Amphotericin B=
Binds Ergosterol ,form membrane pores
electrolyte leakage
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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MOA
Flucytocine=Inhibit DNA synthesis
BY conversion to flurouracil ,interferes with uracil
Caspofungin=
Inhibit cell wall synthesis
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| SmokyWaters
Forum Elite
Topics: 6
Posts: 458
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capsofungin inhibit that through glucan synthase.. 
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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Thanks for adding on to the bit SMOKYWATERS
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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Treatment of sporotrichosis------------>ITRACONAZOLE or POTASSIUM IODIDE
Just to remember-----MOA of AZOLES--------Inhibit Fungal Ergosterol Synthesis
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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CMV -----urine exam is GOLD STANDARD
Look for BASOPHILIC INTRANUCLEAR INCLUSIONS in proximal renal tubular cells
"OWLS eye " appearence is the GIMMIC
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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Rx OF CMV -------Gancyclovir ( 2nd choice = foscarnet)
remember--
Gancyclovir---- inhibits CMV DNA polymerase when phosphorylated by CMV thymidine kinase
Foscarnet ---inhibits viral DNA polymerase BY BINDING TO PYROPHOSPHATE binding site of enzyme
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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INTERACTIONS
1.Methicillin ------------------------------>Interstitial nephritis
2.outdated tetracycline------------------------->Fanconi syndrome
3.remember HEPARIN also causes------------->osteoporosis
4.PHOTOSENSITIVITY------->Sulphonamides, Amiodarone, tetracycline
(SAT for a photo)
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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1.SLE like syndrtome---->Hydralazine, INH, Procaineamide, Phenytoin
(its not HIPP to have lupus)
2.Gynecomastia-------Spironolactone, Digitalis, Cimetidine, Alcohol, Ketoconazole
(Some Drugs Create Awesome Knockers)
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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1. Fluoroquinolones-------->Tendinitis ,Tendon rupture, Cartilage damage.
(ciprofloxacin etc.)
2.Macrolides---------->Acute cholestatic hepatitis
(erythromycin etc)
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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1.Pulmonary fibrosis----->Amiodarone, Bleomycin, Busulphan
(Weak ABB (abs) may cause pulmonary fibrosis)
2. Cardiac toxicity------->Doxorubicin (Adriamycin), Danorubicin
(Ruby broke my heart)
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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TCAs have ------Atropine like side effects.
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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MOA
VINCRISTINE/BLASTINE .PACLITAXEL
1.M-phase specific 1.M-phase specific
2.Bind to tubulin 2.Bind to tubulin
3.Block polymerization of microtubule 3.Hypersatabilize polymerized
microtubules
4.Mitotic spindle cannot form 4.mitotic spindle cannot break
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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MOA
1.Etoposide-------G2 phase specific agent
Inhibit topoisomerase
Increase DNA Degradation
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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MOA
1.Bleomycin ------BREAKS DNA by forming free radicals
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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MOA
1.Dactinomycin -------- Prison Dacoits
Intercalates DNA
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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MOA
1.Cytarabine ---------------- Inhibits DNA polymerase
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| imnalini
Forum Senior
Topics: 10
Posts: 127
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REMEMBER--
ALPHA Amanitin --in death cap mushrooms ---inhibit RNA polymerase 2
IN EUKARYOTES----
RNA polymerase 1 makes-----------r RNA
RNA polymerase 2 makes------------m RNA
RNA polymerase 3 makes -----------t RNA
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