Unknowns
Forum Newbie
Topics: 1
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Hi all ,
What is the mechanism of rebound nasal congestion?
This condition typically occurs after 5 to 7 days of use of topical decongestants
why rebound effect occur?
I wait for responces...
thanks at all ::
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| new_n_lost
Forum Hero
Topics: 732
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Mostly the Nasal decongestants are alpha receptors agonist which block the blood flow to the mucosa, with prolonged vasoconstriction the loses its effect that and there is vasodilation which can be due to tissue hypoxia or drug metabolism at the receptor.
Me 2 cents.
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| Unknowns
Forum Newbie
Topics: 1
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which can be due to tissue hypoxia or drug metabolism at the receptor
very thanks *new_n_lost* for your reply...
but I still want to know why vasodilatation occur...
Nasal decongestants (sympathomimetics) act on alpha 1 receptors and cause VC ....
I ask why with prolonged use of nasal decongestants occur rebound congestion ...
I want alot of Clarification please
thanks again ...
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| milee99
Forum Guru
Topics: 65
Posts: 1,518
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Hi
the mechanism of developing tolerence to these drugs is not well understood
research is being conducted , if interested u may read :
http://clinicaltrials.gov/ct/show/NCT00487032;jse...
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"Vasudhaiva Kutumbakam" - The whole earth is my family.
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| Unknowns
Forum Newbie
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thanks , I will see it ..
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| SmokyWaters
Forum Elite
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tolerance or tachyphylaxis?
when I usd to read in my 3rd year our teacher told us that its because pseudoephedrine depletes all the neurotransmittter plus it also increases the no. of receptors...
after removing the drug effect...there is MORE PRODUCTION as welll as MORE EFFECT...
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| SmokyWaters
Forum Elite
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rebound is because the alpha agonists are overcame by the production machinery of the cell
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| SmokyWaters
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Posts: 447
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