Kamsi
Forum Guru
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A 40-year-old woman with secondary progressive multiple sclerosis continues to have a gradual decline in neurologic status despite treatment with interferon beta. Two years ago she could walk 200 meters without a cane or rest. She has recently worsened to the point that she can walk no further than 25 meters with a walker. On examination, she has bilateral lower-extremity weakness and hyperreflexia. Magnetic resonance imaging of the brain shows multiple white matter lesions in a periventricular distribution.
Which of the following treatments would be most appropriate instead of interferon beta?
A. Chronic oral prednisone
B. Bone marrow transplantation
C. Glatiramer acetate
D. Plasmapheresis
E. Mitoxantrone
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| darkhorse
Forum Elite
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EEEE
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| sprint123
Forum Guru
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Secondary Progressive disease : 2 drugs --> Interferon beta and Mitoxantrone.
In this case, switch her to mitoxantrone with routine ECG monitoring
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| drdg
Forum Senior
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| darkhorse
Forum Elite
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why would u monitor with ecg
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| drdg
Forum Senior
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Mitoxantrone has cardiotoxicity. You need to monitor EKG.
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| darkhorse
Forum Elite
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yes...but cardiotoxicity ...means...they get cardiomyopathy,dilated...and u monitor with MUGA scan....i am unsure of ECG...any thoughts??
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| sprint123
Forum Guru
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You are right darkhorse...The most common side effect of mitoxantrone is dilated cardiomyopathy leading to heart failure. However, MUGA scan routinely is not recommended as a tool for diagnosing cardiac toxicity. ECG could help us determine the size of the chambers.
In addition, rhythm abnormalities are also common with mitoxantrone.
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