peekay
Forum Guru
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what is the reason, we see cytoplasmic immunoglobulin instead of surface.
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| usmleasr
Forum Guru
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i think failure of differentiation...cytoplasmic Ig we see in pre B-cell stage :roll:
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| asmi
Forum Hero
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that M spike is due to cytoplasmic Ig ?
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| usmleasr
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:roll: i am confused..what is the ans peekay??
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| peekay
Forum Guru
Topics: 102
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in pre B cells igs move from cytoplasm to surface. since there is no maturation of pre B cells to B cells . Igs are trapped inside.
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| usmleasr
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but as asmi asked why is the m-spike then?? :?
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| asmi
Forum Hero
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release of gammaglobulins or its precursors are responsible for monoclonal M spike
few cells have russells bodies (contain gamma Ig in their cytoplasm)
:idea: since Ig gamma is found in cytoplasm therefore known as cytoplasmic Ig .They are always monoclonal ( IgG or IgA)--->synthesize more light chains than heavy chains--->excrete light chains in urine(bence jones proteins)
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