asmi
Forum Hero
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what are the MOA's ?
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| jayesh
Forum Junior
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phenytoin acts by blocking Na cond..
s/e gingival hyperplasia, hirsutism, hematologic, osteoporosis(GHOst)
induces P450, teratogenic
valproic acid acts by blocking Na and Ca chan...and inhibit GABA transaminase
s/e hepatotoxic, pancreatitis, alopecia,
inhibits P450, its least sedative, teratogenic
please correct if wrong/ add if i miss
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| mistral92
Forum Senior
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hi jayesh...phenytoin decrease the flux of NA in neurons it also decreases influx of CA during depolarization....
valproic acid....may " enhance" NOT decrease GABA action at inhibitory synapses...
SE hepatic toxicity ( should monitor frequently...
THROMBOCYTOPENIA AND INHIBITION OF PLATELET AGREGAION...so increase BT....
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| Gul
Forum Elite
Topics: 9
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Phenytoin Na channel Block (also class IB antiarrythmic)
side effects :
:arrow: Acne, yellow browning of skin
:arrow: Hirsutism
:arrow: Hepatotoxic
:arrow: Hematotoxic(graulocytopenia, megaloblastic anemia)
:arrow: Gingival hyperplasia
:arrow: skin rash
:arrow: Osteomalacia
:arrow: Nystagmus, ataxia
:arrow: periphrel neuropathy
:arrow: Fetal hydantoin syndrome(cleft lip and palate)
P450 inducer
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| Gul
Forum Elite
Topics: 9
Posts: 259
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Valproic acid : inhibits GABA transaminase
Blocks Na, Ca channels
Inhibits P450
Side effects :
:arrow: Nausea, vomiting
:arrow: Alopecia
:arrow: Tremor
:arrow: Photosensitivity
:arrow: Hepatotoxic
:arrow: Pancreatitis
:arrow: bleeding (thrombocytopenia)
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| mistral92
Forum Senior
Topics: 4
Posts: 185
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hi gul...i 'm not sure that i understand well the MOA of VALPROIC ACID i think that valproic " enhance" action of GABA.... gaba is an inhibitory neurotansmitter so if it's inhibits the GABA tansaminases then GABA increase...is it true???
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| anne
Forum Elite
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GABA transaminase is involved in termination of action of GABA,so inhibiting it would have GABA-ergic effects.
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| asmi
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thanks to all...
one doubt it has been said that dantrolene has similar MOA to phenytoin . I doubt about it ( it was given in q bank kaplan)....anybody would like to clear this to me..thanks in advance
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| mistral92
Forum Senior
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hi asmi... dantrolene acts " DIERCTLY " on muscles by interfering with the release of the CALCIUM from the sarcoplasmic reticulum.
phenytoin stabilizes neuronal membranes to depolarization by decreasing the flux of NA in neurons during the resting state or during depolarization; it also reduces the INFLUX OF CALCIUM ions during depolarization and suppresses repetitive firing of neurons.
hope this will help you...
thanks a lot anne for your explanations.[/b]
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| asmi
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thanks a lot mistral92..so it does have similar acitivity as dantrolene
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