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Prep4USMLE » USMLE Step 1 Forum » Pharmacology Forum » Comments on Morphine


 Morphine  



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GoodGirl

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Oct 22, 2007 - 8:48 AM       #1

Why is Morphine KI in adrenal and thyroid deficiencies?
I know the fact it exaggerates the responses. But why and how ?

Anyone?



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acintya

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Oct 24, 2007 - 10:22 AM       #2

Normally, TSH binds to receptors on the gland which are Gs coupled---Increase cAMP.

But Morphine (an opioid) is Gi coupled and decreases cAMP, so the response to TSH is decreased. Now this would exaggerate the response if the patient is already deficient in thyroid hormone.

This is very similar to the hypothyroidism side effect produced with Lithium treatment.



acintya

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Oct 24, 2007 - 10:30 AM       #3

I guess it is similar for adrenal hormone deficiency as epinephrine is Gs coupled, while the opioids are Gi coupled. Does it sound right??



GoodGirl

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Oct 24, 2007 - 1:52 PM       #4

It gives a sense to me. Thanks, must re-review this topic again,it's necessary to master those G proteins !!!!!!!!!!!! nod No way to escape . wink


ShweHope99.9998

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Nov 02, 2007 - 9:54 PM       #5

wink





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