asmi
Forum Hero
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how do you differentiate it from pellagra ?
What is the defect in hartnup ?
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| Malaysian
Forum Guru
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I think there is some problem in utilizing tryptophan and so (correct me if I'm wrong)tryptophan gets excreted in the urine???
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| meghana jadhav
Forum Elite
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defect in hartnup's disease is
amino acid transportation by therenal and intestinal mucosa is defective
hence amino acids r excreted in urine...
tryptophan is lost
hense deficiency of niacin
.....while
in pellagra it is the dietary deficeincy of amino acid
a negative history for dietary deficiency of tryptophan, in the presence of typical clinical findings should raise the suspicion of Hartnup disease, especially when present in siblings. Chromatographic analysis of the urine usually distinguishes the two
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| mjl1717
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Hartnup -AA tranport of neutral amino acids is impaired in kidney/intestine.
Pellagra-deficiency in vitamin/cofactor niacin (B3)
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