DrVirgo Forum Hero

Topics: 1043 Posts: 3,346
| | 10/18/07 - 11:22 AM  
 
   
 
|   #2 |
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that reduces fever, pain and inflammation. Indomethacin works by reducing the production of prostaglandins. Indomethacin blocks the enzymes that make prostaglandins (cyclooxygenase 1 and 2) and thereby reduces the levels of prostaglandins. As a result, fever, pain and inflammation are reduced.
___________________ Our greatest glory is not in never falling, but in rising every time we fall.
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| DrVirgo Forum Hero

Topics: 1043 Posts: 3,346
| | 10/18/07 - 11:23 AM  
 
   
 
|   #3 |
It's also used to CLOSE a PDA, but I'm uncertain of its mechanism of action for this purpose.
___________________ Our greatest glory is not in never falling, but in rising every time we fall.
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| ing Forum Guru

Topics: 45 Posts: 435
| | 10/22/07 - 10:24 AM  
 
   
 
|   #4 |
If I remembered right, at birth, prostaglandin level drop->PDA close. That why indomethothin will help close PDA, and use prostaglandin to keep PDA open.
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