sfk
Forum Elite
Topics: 47
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Are azoles fungistatic or fungicidal? can somebody answer this, with a proper reference.
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| new_n_lost
Forum Hero
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U can search the Pharma forum cos this discussion has taken place a couple of times if u dont get answered here.
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| Doc750
transfer:step 3 prison
Topics: 52
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it doesn't directly punch a hole in the membrane. It only inhibits the p450 mechanism involved in ergosterol synthesis. therefore --> fungistatic.
on the other hand amphotercin B, binds to ergosterol in the existing membrane and forms a pore "tear" in the membrane, allowing K+ to leak out and killing the organism. So it's fungicidal.
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| sfk
Forum Elite
Topics: 47
Posts: 300
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KLN clearly mentions it to be "fungicidal".
but i came across a question in UW, where it is mentioned to be "fungistatic".
So..........
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| SmokyWaters
Forum Elite
Topics: 6
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its FUNGICIDAL
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| imnalini
Forum Senior
Topics: 14
Posts: 176
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accc to kln fungicidal
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| Ig F
Forum Elite
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they are fungicidal.....
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| vaibhavbora
Forum Elite
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kaplan says cidal ,, uw says static  ???
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VB
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| tia
Forum Guru
Topics: 51
Posts: 1,197
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hi,
its fungicidal....
it inhibits 14 demethylase....inhibiting....ergosterol synthesis...so....leading to a cascade of membrane abnormalities....so fungicidal.
kaplan is correct....
will come back and check...cos even i got this doubt just few days back...
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| DRFP
Forum Guru
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Its cidal no doubt
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| DadooKhan
Forum Junior
Topics: 11
Posts: 50
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Azoles also produce disulfuram like reaction -- amirite?
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