What is the mechanism of cell injury in Hep B infection? ___________________ La vita e bella!
Gul Forum Elite
Topics: 9 Posts: 259
03/21/04 - 09:53 AM
#2
apoptosis?
bluestar Forum Guru
Topics: 236 Posts: 724
03/21/04 - 12:27 PM
#3
agree. . as is the case with many viral diseases. ___________________ I leave no trace of wings in the air, but I am glad I have had my flight
Idiopathic Forum Guru
Topics: 19 Posts: 641
03/22/04 - 06:27 PM
#4
I dont think so...maybe I am wrong, but I thought it was CD8 mediated cytotoxicity.
bobby Forum Guru
Topics: 136 Posts: 569
03/23/04 - 02:36 AM
#5
CD8+ T cell mediated cytotoxicity of Hep. cells infected with the virus and thus present the Ag ___________________ if you haven't any charity in your heart, you have the worst kind of heart trouble.
Gul Forum Elite
Topics: 9 Posts: 259
03/23/04 - 08:17 AM
#6
Thank u
bluestar Forum Guru
Topics: 236 Posts: 724
03/23/04 - 06:17 PM
#7
hmm... is that something we can only keep in mind or we can assort it to something common? I don't agree with the study mothod of merely "memorizing", but would rather find some logic in the truth that we can deduct. Any idea in this case why it's CD8 cytotoxicity vs apoptosis? ___________________ I leave no trace of wings in the air, but I am glad I have had my flight
dyk33 Forum Newbie
Topics: 7 Posts: 29
03/23/04 - 07:22 PM
#8
how do CD 8 cells kill? 1) perforin granzyme dependent killing here, perforin punctures hole and granzyme goes into cells, which then activate apoptosis pathway.
2) Fas-Fas ligand dependent killing which also activate apoptosis pathway.
thus, i don't think CD 8 cell mediated cytotoxicity and apoptosis are mutually exclusive.
krsma Forum Elite
Topics: 40 Posts: 227
03/27/04 - 12:46 AM
#9
Info from internet source:
the host immune system attacks the HBV and causes liver injury. Activated CD4+ and CD8+ lymphocytes recognize various HBV-derived peptides located on the surface of the hepatocytes, and an immunologic reaction occurs. Impaired immune reactions (eg, cytokine release, antibody production) or relatively tolerant immune status results in chronic hepatitis. In particular, a restricted T cell–mediated lymphocytic response occurs against the HBV-infected hepatocytes.
bluestar Forum Guru
Topics: 236 Posts: 724
03/28/04 - 01:02 PM
#10
Thank you very much, usmle4me and dyk33! ___________________ I leave no trace of wings in the air, but I am glad I have had my flight
bobby Forum Guru
Topics: 136 Posts: 569
05/07/04 - 03:19 AM
#11
"Bela" wrote: What is the mechanism of cell injury in Hep B infection?
i got this question almost word for word during the exam. ___________________ if you haven't any charity in your heart, you have the worst kind of heart trouble.
