yunuz
Forum Junior
Topics: 17
Posts: 66
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Guys I am reading virology from Kaplan notes.
In classificaion, they write all RNA viruses are SS except Reovirus.
Reovirus are also segemnted.
But I cannot find this "reovirus"in their tables:
the (+)sens RNA are calci, picorna, flavi,toga, corona, retro V.
The (-) sens are paramyxo,rhabdo, flavi,orthomyxo, bunya, and adeno.
No trace of reovirus!
So what are these reovirus and what doe this group comprise?
Thanks
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| drgho
Forum Junior
Topics: 1
Posts: 115
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Reo is double-stranded RNA virus. Well-known member in this group is rotavirus: common cause of gastroenteritis in children.
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| yunuz
Forum Junior
Topics: 17
Posts: 66
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Thank drho.
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| SmokyWaters
Forum Elite
Topics: 6
Posts: 458
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reoviridae genome is transcribed conservatively causing an excess of (+) sense strands, which are used as mRNA templates to synthesize (-) sense strands
most important ones are
ROTA VIRIDAE and colorado tick fever causing virus
Infection with human rotavirus (HRV) appears to cause a substantial portion of cases of gastroenteritis occurring in children aged 6 months to 2 years. The rotavirus particle consists of an 11 double-stranded RNA genome enclosed in a double-shelled capsid. The outer shell is composed of a major glycoprotein with a molecular weight of 34,000 (ie, viral protein [VP]7) and a minor, trypsin-sensitive protein with a molecular weight of 84,000 (ie, VP4, previously designated VP3). Four proteins (ie, VP1, VP2, VP3, VP6) make up the virus core. Six nonstructural (NS) proteins (ie, NS53, NS34, NS35, NS28, NS26, NS12) also are produced during rotavirus infection.
Trypsin cleavage of VP4, which yields 2 polypeptides, VP8 and VP5, with molecular weights of 27,000 and 58,000, respectively, is required for the activation of infectivity. Originally, serotyping was based solely on differences in the VP7 protein because animals hyperimmunized with rotaviruses develop most neutralizing antibody to this protein. Cross-neutralization studies conducted with these hyperimmune sera readily separated the strains into VP7 serotypes. Later, a dual serotyping scheme was developed when VP4 was discovered to be the dominant neutralization protein in some cases. Rotavirus serotypes include a description of both the VP4 (protease-sensitive protein, P) and the VP7 (glycoprotein, G) types
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