asmi
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How do you differentiate both ?
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| Gul
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Papillary Carcinoma thyroid
:arrow: Most common Ca thyroid
:arrow: histologically: tumor cells having papillary projections with ground glass appearance (orphan annie nuclei), psammoma bodies
:arrow: there can also be a Hx long term radiotherapy
:arrow: Lymphatic spread
:arrow: prognosis is good 20 yrs. survival rate 90%
Follicular carcinoma:
F for follicular F for females
:arrow: heamatogenous spread
:arrow: poorer prognosis than papillary
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| anne
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which thyroid tumor cant be biopsied by FNAC(fine needle aspiration cytology)?
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| asmi
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thanks gul,
anne i have to look for the answer....my ignorance/forgtfulness :oops:
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| bluestar
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anybody can explain what it means by "orphan annie nuclear"? I don't know who is orphan annie. :oops: Thanks.
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| Bela
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Hehehehe. You never saw the movie Annie, with the cute little red haired orphan, whose eyes are of blue color? She has crystal eyes 
Now, in papillary carcinoma of the thyroid, the nuclei are ground glass, just like annie's eyes. At least this is what I think. Correct me if I am wrong.
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| bluestar
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thanks for the reply. but isn't ground glass kinda roughened and nontransparent? that way it shouldn't be like a crystal-y-bright eyed orphan annie. :P any other thoughts?
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| Bela
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Hmmm, what i meant when I said that these nuclei are like crystal is that I wanted to say that they're clear or empty, and that is where they got the name GROUND-GLASS nuclei. However I could be wrong.
Now, I remember that Robbins Pathology has a picture of these types of nuclei, so I suggest you take a look so that you know what they look like.
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| bluestar
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Gotcha. I don't have the book but I found one on the web. Basically they are cells with clear nuclei.
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| anne
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fnac can be used to diagnose all types of thyroid tumors except for follicular.
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| asmi
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thanks anne,
another Q
80 yrs olf women has multiple long standing lesions on face, back.These are well circumscribed lesions,tan to brownish colour , slightly raised with rough surface ,0.5 to 1.5 cm in diameter .When examined the lesion were able to be peeled away with scalpel blade .What is the diagnosis ?
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| Gul
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Dont know the answer to above question but would like to know its answer and to that one with FNAC...Y cant we do FNAC in Follicular CA?
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| asmi
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sebhorric keratosis..
is it premalignant ?
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| usmleasr
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FNAC shouldnot be done in a thyrotoxic state .....
for follicular carcinoma FNAC is not informative ..that is it...it is not contraindicated....if u see follicular mophology in FNAC u r not sure whether it is benign or malignant..u need biopsy as a further step to demonstrate capsular invasion
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| asmi
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will look into it..but i think FNAC is not high yield Q .Is it ?
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| bluestar
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Another question, how does APKD cause anemia? I only know it can cause 2nd polycythemia.
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| asmi
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it causes anemia by decreased erythropoietin synthesis
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| Gul
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Or we could say that it uses up the erythropoietin (as it 1st causes polycythemia)?
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| asmi
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"asmi" wrote:
sebhorric keratosis..
is it premalignant ?
:idea: its not premalignant
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| bluestar
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ah, that makes sense. thank you, Gul and asmi.
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