peekay
Forum Guru
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MHC-I
a-found on all nucleated cells.
b-three gene loci(HLA A,B,C)
c-antigens are identified by HLAantibodies
c-present ag to CD8+ cells
MHC-II
a- found on immunologic effectors cellls(macrophages.B cells,activated epis)
b-three gene loci(HLA DP,DQ,DR)
c-antigens are identified by cellular reactions
c-present ag to CD+cells
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| Quinn
Forum Elite
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Right,  but there is more....
How is each bound to antigen and presented on the cell surface? Where is the antigen bound?
Note that the MHC I is found on platelets. Also, both have codominate expression...i.e. your cells express HLA-A, HLA-B, and HLA-C inherited from both your mom and dad.
Which one is down regulated in HIV? How?
Which one has gene loci that are associated with Type I Diabetes? Hemochromatosis?
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| peekay
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you are right. i forgot about their chemical coposition.if u could add that
D.M is assoiated with MHCII.
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| jayesh
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in addition to above,
MHC-1 bind with endogenous peptides
has beta-2 microglobulin
no invariant chain
is down regulated by HIV (nef)
MHC-2 bind with processed exogenous peptides
no beta 2 microglobilin
has invariant chain
also asso with DM
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| Quinn
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Nicely done Jayesh
Hemochromatosis is assoc. with HLA-A
Specifically type I DM is HLA-DQ -DR3 and -DR4
Nice
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| usmleasr
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hey nice discussion..what MHC DR-2,DR-3 ASSOCIATED WITH?
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| asmi
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DR2 for multiple sclerosis and DR3 for type I diabetis
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| Gul
Forum Elite
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Rh. arthritis HLA DR4
Hashimoto's Thyroiditis HLADR5
Celiac HLAB8
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| jay1
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This is a nice discussion.I found all this info at one place .....in Kaplan's Immunology Notes! So, it means Kaplan's Notes are a good source for this relatively new subject ? I am asking this because i read different reviews about immunology!
Thanks
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| asmi
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hemochromatosis..with HLA-A3
celiac disease..HLA-B8 and DR3
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| Quinn
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Your are right asmi....hemochromatosis is HLA-A3...i left off the "3"
Here is a list of the HLA's that I know of
-DR2 .....Multiple Sclerosis, Hay Fever, Goodpastures, Narcolepsy
-DR3......Type I DM (also -DQ & -DR) , SLE, Celiac Sprue (also -B8 & -DQ)
-DR4......Type I DM, Pemphigus Vulgaris, Temporal Artiritis, Lyme Disease
Rhematoid Arthritis
-DR5......Juvenile Rheumatoid Arthritis, Pernious Anemia, Hashimoto's
-DR7......Steroid Responsive Nephroitc Syndrome
-B27.......Ulcerative Colitis, Psoriasis, Ankylosing spondylitis,
Inflammatory bowel Ds, Reiter's syndrome
-A3.........Hemochromatosis
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| jayesh
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thanx Quinn
now its easy to remember
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| asmi
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thanks quinn
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| Quinn
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Thanks guys (peekay, jayesh, asmi etc)....really enjoyed the exchange.....definately have to do again. :lol:
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| mdwannabe
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DR2 protective in DM 1
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| mdwannabe
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also MHC I is a ligand for KIR on NK cells
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