abcab740
Forum Junior
Topics: 11
Posts: 35
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High level resistance of Mycobacterium tuberculosis to isoniazid (INH) involves
A. decrease intracellular accumulation of the drug
B. inactivation of the drug via N-acetyltransferase
C. increase synthesis of mycolic acids
D. mutations in gene coding for DNA-dependent RNA polymerase
E. reduced expression of the gene encoding a catalase
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| Gul
Forum Elite
Topics: 9
Posts: 259
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Option E is the right answer (gene is Cat K gene )
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| usmleasr
Forum Guru
Topics: 105
Posts: 970
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B :roll:
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| Colombia
Forum Guru
Topics: 85
Posts: 438
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E. IHN is a pro-drug that must to be oxidazed to activate
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| usmleasr
Forum Guru
Topics: 105
Posts: 970
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yes i agree with u all
http://www.auburn.edu/~goodwdc/
it is catlase absence ....
to add with this q..what is the mechanism of resitance for rifampicin, ethambutol , pyrizanamide...(as MDR TB is increasing )
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| asmi
Forum Hero
Topics: 1043
Posts: 4,609
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For rifampin its D.
for ethambutol...C ?
PZ..they lack bioactivating enzyme
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| abcab740
Forum Junior
Topics: 11
Posts: 35
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ethambutol- mutation of embB gene in TB
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