krsma
Forum Elite
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What are unopposed estrogens?
for example: Kaplan pathology notes states that unopposed estrogens have increased risk of endometrial and breast cancer, pg. 85.
so what are they talking about? i'm not getting it!!!
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| Gul
Forum Elite
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I dont know specific situations but i can understand from this that they mean estrogen without combination i.e progestrone
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| asmi
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I think it means the free estrogen,which is not bound to plasma proteins and thus will have more effect .
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| galleta
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Unopposed estrogen means taking estrogen replacement alone. This was done in the early days for treatment of menopause. However, the result was that there was proliferation of the uterine lining leading to hyperplasia and an increased risk of endometrial cancer. Now, estrogen/progestin combination is used (the progestin "opposes" the action of estrogen and prevents endometrial hyperplasia from occuring). However, if the postmenopausal patient has had a hysterectomy, then they can be given estrogen alone.
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| Gul
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so that means I was thinking on right track?........right??
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| mjl1717
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Right! :!:
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Smell the coffee! "Is That an Osler move??"
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| krsma
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thanks, that was very helpful, now I understand
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