Infusion rate

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Infusion rate

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yunuz
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09/26/07 - 12:44 PM

A 75 yo man is given an infusion of lidocain for the ctrl of Ventricular tachycardia.A dose adjustement is required.Which of the following parameteres would be most important in determining the infusion rate that is therapeutically effective and non toxicc

a-Bioavailability.

b-Clearance

c-GFR

d-Plasma binding protein

e-Volume distribution

alaa_abes2
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09/29/07 - 05:50 AM

i think

d

becz apart of drug will be free andapart will be bound(reservoir)

when pbp decrease therabeutic dose may be toxic as free amount of drug will increase
as in starvation

yunuz
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09/29/07 - 10:04 PM

Sory no.Plasma binding protein is incorrect.

vnty
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09/30/07 - 03:02 PM

confusedoc
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09/30/07 - 05:27 PM

b- clearance

hope4dabest
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09/30/07 - 06:22 PM

drgho
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10/01/07 - 01:03 AM

yunuz
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10/01/07 - 07:32 AM

The correct answer is B:Seady state concentration(Cs) of a drug equals to input devided on ouput.The input is rate of ifusuion and output is clearance.Therefore the theraupeutic dose will depend on the clearance knowing the infusion rate.

alaa_abes2
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10/01/07 - 08:48 AM

thanks