me007
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elitoki wrote:
Anemia in elderly + inflammatory joint disease: Iron def. Anemia
are you sure?
were he is loosing his iron in inflammatory joint disease ?
might be AOCD?
elitoki wrote:
Anemia in elderly + lymphoproliferative disorder : ?????
=AOCD
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| me007
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it's it IM lecture notes, "AOCD can accompany virtually any chronic inflammatory, infectious or neoplastic conditions"
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| Justice
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elitoki wrote:
plz help me to complete the most common anemia in elderly :
Anemia in elderly + Degenerative joint disease: AOCD
I recall a Q in UW bank which stated that osteoarthritis does not lead do AOCD by itself but may be seen in Pts on chronic use of NSAIDs... So, the cited statement is true only under certain conditions...
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| Justice
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elitoki wrote:
Anemia in elderly + inflammatory joint disease: Iron def. Anemia
I also doubt in this... This should be AOCD
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| elitoki
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me007 wrote:
it's it IM lecture notes, "AOCD can accompany virtually any chronic inflammatory, infectious or neoplastic conditions"
This summary that I made is based on UW.
One of the answer of the Q said that Degenerative joint disease (is chronic disease) can cause AOCD, but inflammatory joint disease (I think it is acute) cause iron deficiency anemia. I want to be sure if that statement is correct.
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| Justice
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me007 wrote:
it's it IM lecture notes, "AOCD can accompany ... neoplastic conditions" May be true for any malignancy except those involving bone marrow hyperproliferation...
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| elitoki
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Justice wrote:
This should be just normochromic normocytic HYPOCELLULAR anemia...
You are right Justice. but I'm confused
In one they said NHL/CLL in elderly cause hemolytic anemia, and the another said bone marrow infiltration cause anemia in those pte.
Is it the same??? I don't get it???
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| Justice
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AOCD:
The main causes of this anemia include:
# Chronic infections : tuberculosis, lung abscess, subacute endocarditis
# Non infectious inflammatory diseases : rheumatoid arthritis, systemic lupus erythematosus, arteritis giant cell (temporal), tecidual injury (fracture).
# Neoplastic Disorders : Hodgkin`s disease, lung and breast carcinoma.
Pathogenesis
Anemia of chronic disease is characterized by a small decrease of the half-life of red cells, caused either by a disturbance of the iron metabolism or by resistance to erythropoietin action.
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| Justice
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elitoki wrote:
In one they said NHL/CLL in elderly cause hemolytic anemia, and the another said bone marrow infiltration cause anemia in those pte.
Autoimmune hemolysis, warm-type IgG... Seen in NHL and CLL; cold-type AIHA-seen in Pts with Waldenström’s macroglobulinemia
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| elitoki
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| Justice
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Man, do not be confused... Most important, I think, is that your sources do not teach you that there is only one mechanism of anemia in Pts with lymphoproliferative disorders... Mech-ms are immune and non-immune, and they overlap each other...
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| elitoki
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ok! I'll look up again those Qs. and try to understand what they want to answer.
Thanks Justice~
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| me007
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http://moffitt.org/moffittapps/ccj/v5ns/article10...
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| me007
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Justice wrote:
Pathogenesis
Anemia of chronic disease is characterized by a small decrease of the half-life of red cells, caused either by a disturbance of the iron metabolism or by resistance to erythropoietin action.
additional from from pathology step 1
pathogenesis of AOCD:
iron is trapped in bone marrow macrophages and is unable to be used to synthesize Hb.
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| elitoki
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Wow !! Thanks me007. 
I'm happy again~
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