dr.sunshine0519
Forum Newbie
Topics: 7
Posts: 39
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i think its D too , I know it cant be a c or e
Whats the answer?
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| sureshrx
Forum Newbie
Topics: 5
Posts: 33
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answer is d. mg normally binds and blocks opening of ca and na channels in NMDA receptor when the cell is in resting membrane potential. glutamate which is excitatory neurotransmitter opens these channels allowing influx of ca or Na and thus causing depolarisation....this channel also blocked by drug dizocilpine.
this is important in treatment of stroke as the "penumbra" region has lost its ability to clear local glutamate as they have lost the ability to maintain the transmembrane Na gradient that drives glutamate uptake. this leads to activation and excitotoxic damage.
glutamate and its congeners are unique in that when they act on neuronal cell bodies , they can produce so much Ca influx that neurons die
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| sureshrx
Forum Newbie
Topics: 5
Posts: 33
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answer is d. mg normally binds and blocks opening of ca and na channels in NMDA receptor when the cell is in resting membrane potential. glutamate which is excitatory neurotransmitter opens these channels allowing influx of ca or Na and thus causing depolarisation....this channel also blocked by drug dizocilpine.
this is important in treatment of stroke as the "penumbra" region has lost its ability to clear local glutamate as they have lost the ability to maintain the transmembrane Na gradient that drives glutamate uptake. this leads to activation and excitotoxic damage.
glutamate and its congeners are unique in that when they act on neuronal cell bodies , they can produce so much Ca influx that neurons die
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| sureshrx
Forum Newbie
Topics: 5
Posts: 33
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i guess this answer could be derived from pure common sense as amrit and dr sunshine has proven. which pharmaceutical company would bring out a drug which raises seizures potential?
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| eytanraz
Forum Newbie
Topics: 1
Posts: 68
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imipenem teaches that it is possible...
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| mikky
Forum Elite
Topics: 17
Posts: 421
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nice explanation...
thanx sureshrx
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it is our choices that show what we truly are, far more than our abilities!!!!
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| SmokyWaters
Forum Elite
Topics: 6
Posts: 447
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some more facts about NMDA receptor...
it requires AMPA receptor to function
it requires GLYCINE to function
Mg is required by it to block the channel
calcium and sodium both can pass through it
it causes depolarization
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