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yunuz
Forum Senior  Topics: 17 Posts: 67 |
ACE Inhobitors are contreindicated in the case of hypertention due to renal stenosis. Any one knows the reason for that? Thanks
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Auron
| Forum Newbie Topics: 1 Posts: 10
ACE inhibitors block the production of Ang II which preferentially constricts the efferent arteriole, effectively decreasing renal blood flow while increasing GFR(filtration fraction goes up). If someone has renal artery stenosis, renal blood flow is reduced and they are dependent on increased efferent arteriole pressure to maintain their GFR. If you knock out AngII, GFR goes down and renal failure may ensue.
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yunuz
| Forum Senior Topics: 17 Posts: 67
Thank you. It makes sens
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Ig F
| Forum Guru  Topics: 3 Posts: 500
cool.u made it sound really easy and understandable.... 
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vaibhavbora
| Forum Guru  Topics: 38 Posts: 467
good q
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DadooKhan
| Forum Newbie  Topics: 17 Posts: 78
Auron wrote: ACE inhibitors block the production of Ang II which preferentially constricts the efferent arteriole, effectively decreasing renal blood flow while increasing GFR(filtration fraction goes up). If someone has renal artery stenosis, renal blood flow is reduced and they are dependent on increased efferent arteriole pressure to maintain their GFR. If you knock out AngII, GFR goes down and renal failure may ensue. very nicely said. And this is a good Q, as I was somewhat unclear about this as well.
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