kity
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Rx of cystinuria??
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| kity
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newborn with ketoacidosis???
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| LilInjnDatCould
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kity wrote:
Rx of cystinuria??
In cystinuria, the problem is with inablity to reabsorb Cystine, Ornithine, Lysine and Arginine (COLA) b/c of defect in the carrier protein that reabsorbs all these four AAs in the proximal tubule. Lack of reabsorbtion can result in calculi formation and thereby obstruct the urinary tract.
Since, the urine is very acidic with all these AAs - and thereby these AAs will remain clumped, so you want to alkanilize it by using something like a Carbonic Anhydrase Inhibitor like Acetazolamide. The alkaline environment will ionize the AAs and cause them to become solubulized into the urine to help with the excretion. They can also get extra oral hydration treatment to help with the dilution of the urine.
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| kity
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Thanks LilInjnDatCould
you seem to have really good understanding of things.. I really never knew this detail of it.. Thanks again 
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| kity
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kity wrote:
newborn with ketoacidosis???
I myself forgot the enzyme name now
let me check
propionylcoA carboxylase defeciency or methylmalonyl coA mutase defeciency
leads to accumulation of odd chain AA..
other sx.. hyperammonemia, metab acidosis, lethargy, N?V failuure to thrive in neonates..
Rx avoid odd chain AA..
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| kity
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no Qns so I will leave one..
tissues having -
GLUT1
GLUT2
GLUT3
GLUT4
??
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| simi
Forum Elite
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GLUT 1..... MOST TISSUES(brain n redcells)
GLUT 2.......liver ,pancreatic beta cells
GLUT 3.....MOST TISSUES
GLUT 4......Sk ms n adipose tissue
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| simi
Forum Elite
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A common football injury caused by clipping from the lateral side will damage what structures (3 answers)?
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| simi
Forum Elite
Topics: 53
Posts: 358
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one more qs...i don't think its high yield but came across this qs..
A prototroph such as wild type E.coli is growing in minimal salts n glucose medium..if amino acid histidine is added to the growth medium ..what could the cells most immediate response with effect to its biosynthesis of histidine?
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| simi
Forum Elite
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Posts: 358
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options..a)histidine synthesis would be accelerated
b)histidine synthesis would be slowed following direct inhibition of enzymes essential to that particular pathway
c)enzymes involved in histidine synthesis would be in hibited by the added histidine
d)the first enzyme in the biosynthetic pathway would be inhibited by histidine
e)all biosynthetic pathways in the cell would be inhibited
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| edie
I can, and I will.
Topics: 26
Posts: 1,235
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LilInjnDatCould wrote:
i guess y'all didn't like my question. maybe not clinically relevant enough.. well, here is the answer nonetheless...
The difference between triglyceride and sphingolipids is the backbone is a serine instead of a glyecerol molecule.
Now the three major classes of sphingolipids differ by what is attached at the 3rd position of the Ceramide molecule (remember a Ceramide is a Serine backbone with 2 Fatty acids).
1)A ceramide with a simple sugar @ 3rd position (like a glucose or galactose) makes it a cerebroside. Deficiency/absence of glucocerebrosidase results in glucocerebroside in Gaucher's Dz! - rem: "crumpled or wrinkled paper" inclusions in lysosomes of their macrophages.
2)A ceramide with a complex sugar like @ 3rd postition (i.e an amino sugar) makes i a ganglioside. Deficiency/absence of HexosAMINIdase A results in Tay-Sachs dz with accumulation of Ganglioside GM2 - rem: "cherry red spot" of the macula in the retina. Also, Psychomotor retardation due to the the accumulation in the cns and thereby irreversibly neurological damage. Die b4 5 yrs age.
3)In the last class a ceramide complexes with a phopho-choline giving a sphingomyelin. Accumulation of sphingomyelins due to a deficiency of sphingomyelinase will result in Neimann-pick dz. These pts exhibit a mixture of both of the above Sxs. They also have Cherry red spot in macula, but they have a destinct "zebra body inclusions" on EM.
I guess it's a bad question, my bad.
Guys, please know these backwards and forwards. Also, study the EM, micro and histo pics associated.
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| hope4dabest
Forum Elite
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Posts: 433
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simi wrote:
options..a)histidine synthesis would be accelerated
b)histidine synthesis would be slowed following direct inhibition of enzymes essential to that particular pathway
c)enzymes involved in histidine synthesis would be in hibited by the added histidine
d)the first enzyme in the biosynthetic pathway would be inhibited by histidine
e)all biosynthetic pathways in the cell would be inhibited
just a fluke--B.....
plzz give explaination for the right choice
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| keepgoing
Forum Guru
Topics: 62
Posts: 1,673
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simi wrote:
A common football injury caused by clipping from the lateral side will damage what structures (3 answers)?
medial meniscus,medial collateral ligament,and ant.cruciate ligament-->unhappy triad
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| keepgoing
Forum Guru
Topics: 62
Posts: 1,673
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simi wrote:
one more qs...i don't think its high yield but came across this qs..
A prototroph such as wild type E.coli is growing in minimal salts n glucose medium..if amino acid histidine is added to the growth medium ..what could the cells most immediate response with effect to its biosynthesis of histidine?
inhibit histidne biosynthesis,i guess.
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| keepgoing
Forum Guru
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1.effect of LH on adrenal androgen production??
2.right or left vagus which innervates--SA & AV node??
3.what part in GIT absorbs water soluble vitamins?
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| simi
Forum Elite
Topics: 53
Posts: 358
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keepgoing wrote:
medial meniscus,medial collateral ligament,and ant.cruciate ligament-->unhappy triad
YUP
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| simi
Forum Elite
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Posts: 358
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ans to histidine qs is D.
If histidine is added to the growth medium the first enzyme in biosynthetic pathway would be inhibited.Control over enzyme activity seems to be responsible for the moment to moment control of intermediary metabolism.During this regulatory process known as feedback inhibition..a metabolite binds to an allosteric enzyme causing it to gain or loose catalytic activity.
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| simi
Forum Elite
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.These activators n inhibitors r intermediates of metabolsism n act as effectors..the concentration of end products of various pathways allow the cell to moniter n regulate the flow of materials providing the most efficient use of resources.This control serves to maintain a relatively constant internal concentaartion of metabolites in the face of changing demands for them n their availability in their medium.
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| simi
Forum Elite
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Posts: 358
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Usually only the first enzyme in biosynthetic pathway is regulated.Inhibition of later enzymes causes wasteful accumulations of intermediates inthat pathway.The rate of synthesis is not directly increased by the added nutrient,nor is the rate of synthesis slowed down coz of direct inhibition of enzymes required by the pathway.Only specific pathway(hisytidine for eg)affected by this control process.No specific end product(one amino acid eg) is able to effect all other amino acid pathways.
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| simi
Forum Elite
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keepgoing wrote:
1.effect of LH on adrenal androgen production??
2.right or left vagus which innervates--SA & AV node??
3.what part in GIT absorbs water soluble vitamins?
1.LH has no effect on adrenal androgens i guess
2.Rt. vagus nr- SA node Lt VAGUS nr.. AV node
3.small intestine?
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| simi
Forum Elite
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Common peroneal nerve damage manifests what deficit?
Common peroneal, Tibial, Femoral, and Obturator nerves arise from what spinal cord segments (4 answers)?
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| simi
Forum Elite
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Femoral nerve damage manifests what deficit?
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| amritt786
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hey , come on where u all gone this was good stuff, kity where r u u r author of this quizzzzz dont let it die
MC cause of interstitial pneumonia after kidney transplant? treatment?
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| kity
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hey amritt786
I am at almost at end of my journey so have to concentrate on all lil bits now..
so I am off now frm this Quiz whch might b demoralizing for me a lil.. like just now..
EVERYONE FEEL TO CONSIDER THIS THREAD AS YOUR OWN. & continue if you think it can benefit you..
I think ans is CMV??? Rx..gancilovir
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