A 40-year-old male was diagnosed with an undifferentiated carcinoma of the lung. Despite treatment with chemotherapy, he died of widespread metastases. At autopsy, tumor was found in many organs. Histologic examination revealed many foci in which individual tumor cells appeared shrunken and deeply eosinophilic. Their nuclei showed condensed aggregates of chromatin under the nuclear membrane. The process affecting these shrunken tumor cells was triggered by the release of which of the following proteins into the cytosol? (A) Lipofuscin (B) Cytochrome c (C) Catalase (D) Phospholipase (E) bcl-2 ___________________ Forum Elite, But Step 2 Newbie....
Jackofknives Ipwnpoker.com
Topics: 91 Posts: 707
09/05/07 - 11:10 PM
#2
here s a guess
(B) Cytochrome c ___________________ There are many things in this world that can’t be changed no matter how hard you try. That’s why you must not hesitate when the time comes where you have to give it all you’ve got.
hope4dabest Forum Elite
Topics: 16 Posts: 433
09/06/07 - 12:02 AM
#3
among thse i guess only cytochrome c is apo-pototic but m not sure if its released in cytosol
drgho Forum Junior
Topics: 1 Posts: 115
09/06/07 - 12:29 AM
#4
cytochrome c. There are two pathways to initiate apoptosis : through receptor like Fas-FasL and mitochondrial pathway. In mitochondrial pathway, the end result is the release of cytochrome c from mitochondrial matrix into cytosol and cytochrome c forms complex with apaf-1 and caspase 3 to induce apoptosis.
sfk Forum Elite
Topics: 43 Posts: 294
09/06/07 - 06:38 PM
#5
way to go, drgho. are u an apoptosis expert or something?!! ___________________ Forum Elite, But Step 2 Newbie....
drgho Forum Junior
Topics: 1 Posts: 115
09/06/07 - 11:12 PM
#6
sfk wrote: way to go, drgho. are u an apoptosis expert or something?!!
oh..not expert....just had taken some courses in cancer research....
Ig F Forum Elite
Topics: 3 Posts: 439
02/08/08 - 07:25 AM
#7
B...cytochrome C... ___________________ i m not perfect but i wanna get close to it......
cytochrome c. There are two pathways to initiate apoptosis : through receptor like Fas-FasL and mitochondrial pathway. In mitochondrial pathway, the end result is the release of cytochrome c from mitochondrial matrix into cytosol and cytochrome c forms complex with apaf-1 and caspase 3 to induce apoptosis.
