Recurrent Infections

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Recurrent Infections

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sfk
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09/05/07 - 08:58 PM

As a 4-year-old child, this patient had recurrent sino- puhnonary infections with Staphylococcus aureus and Streptococcus pneumoniae; he also developed an arthritis that cleared with immunoglobulin therapy. The germinal centers of his lymph nodes are rudimentary, and he has developed SLE. Which type of cell failed to differenti-ate?

(A) Follicular dendritic cell
(B) Neutrophil
(C) Pre-B cell
(D) Pro-T cell
(E) Stem cell
(F) Type 1 helper T cells (TH1)

Edited by sfk on 09/05/07 - 10:14 PM

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hope4dabest
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09/05/07 - 09:08 PM

E????

sfk
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09/05/07 - 10:16 PM

try again hope4da best, i had messed up the question, corrected it now.

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hope4dabest
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09/05/07 - 11:50 PM

its C....plz post expla...i want to know abt role of A

kpalam
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09/06/07 - 11:57 AM

kpalam
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09/06/07 - 12:09 PM

i think C b/c dendritic cell will present antigen to helper CD4 T cell which then produce cytokin to stimulate differentiation of preB cell into antibody producing mature B cell or plasma cell.

unique1
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09/06/07 - 12:40 PM

C

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mytime
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09/06/07 - 12:41 PM

unique1 wrote:
C

sfk
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09/06/07 - 06:43 PM

the answer is c, but doesnt the clinical presntation point towards a common variable immune deficiencey rather than agammaglobulinemia???

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kpalam
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09/06/07 - 10:46 PM

#10

i am wrong . actually cytokins stimulate mature B cell to divide and differentiate into antibody producing plasma cell that take place in secondary lymphoid organ as lypmphnode.

ans is (C). Brutons hypogamaglobulinemia.

not common variable because
common variable occurs in late teens to early 20s.germinal center of lymphnode is hyperplastic vs rudimentary in Brutons.
also in Brutons there is association of autoimmune diseaselike SLE, dermatomyositis.Arthriris is belived to be infectious in origin like mycoplasma infection.
smiling face

sfk
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09/07/07 - 08:39 AM

#11

silly me!! i completely missed the rudimentary follicles. sticking out tongue

but what about arthritis which clears with immunoglbulins?

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kpalam
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09/09/07 - 06:26 AM

#12

sfk wrote:
silly me!! i completely missed the rudimentary follicles. sticking out tongue

but what about arthritis which clears with immunoglbulins?

sorry for late reply.
according to robins path--35% children with brutons develop arthritis that clears with restorative immunoglobulin therapy. this arthritis believed to be infectious in origin. nod

Ig F
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02/08/08 - 07:17 AM

#13

rudimentary follicles--------absence of pre-B cells.... nod

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new_n_lost
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02/08/08 - 04:39 PM

#14

kpalam wrote:
i am wrong . actually cytokins stimulate mature B cell to divide and differentiate into antibody producing plasma cell that take place in secondary lymphoid organ as lypmphnode.

ans is (C). Brutons hypogamaglobulinemia.

not common variable because
common variable occurs in late teens to early 20s.germinal center of lymphnode is hyperplastic vs rudimentary in Brutons.
also in Brutons there is association of autoimmune diseaselike SLE, dermatomyositis.Arthriris is belived to be infectious in origin like mycoplasma infection.
smiling face

Good Explanation Should be made into a note.

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