sfk
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Many drugs that are used to treat cancer cause death of tumor cells by apoptosis. Mutational inactivation of which of the following genes can render tumor cells resist-
ant to the effects of such chemotherapeutic drugs?
(A) bcl-2
(B) p53
(C) NF-B
(D) P450
(E) Granzyme B
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| tompat
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A
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| hope4dabest
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P53
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| dallas
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D. p53
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| new_n_lost
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Guys i have to agree with Tompat cos thoug p53 is known to have been involved in Apoptosis but the Resistence to Apoptosis is due to bcl-2 overexpression. Bax is ur apoptosis gene and BCL-2 is ur Anti-Apoptosis Gene. Furthermore P53 is only activated when there is damage to DNA. If the DNA gets damaged due any reason and is unsalvagable then p53 plays a role but if its not then it doesnt, u can say its a back up gene for apoptosis but ur initial one is Bax.
My 2 cents.
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| Ujk
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A
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| amritt786
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A
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| drgho
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B. p53. This is the only pro-apoptotic gene listed. Inactivation of it will make tumor cells less apototic and resistant to such chemotherapeutic. Bcl 2 is anti-apoptotic and in other words, its inactivation will cause more apoptotic cell death. Also, DNA damage is not the only factor activating p53. There are other cellular stress causing p53 activation and inducing tumor cell apoptosis and its inactivation can cause tumor cells resistance to apoptosis.
Edited by drgho on 09/05/07 - 09:11 AM
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| new_n_lost
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lol Damn u r so right. Again i totally missed it this was asked the other way around. See this is how careless i m; Damn i hate that. they asked the Inactivation of the Gene and here i m yapping abt BCL-2 how really dumb of me.
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| new_n_lost
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the last time i did this question i made the same mistake,
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| sfk
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yes, its p53. i dont think i need to post the explanation, drgho has made it clear and simple.
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| silver
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Late for the party!...but yeah, p53 it is!
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| tompat
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doh i did this q 2nd time and selected my ans as b, and was surprised by my 1 st response
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| kpalam
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very very helpful discussion. thanks all.
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| sataleees
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Great, thanks for all.
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| SmokyWaters
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B...its DEFINITELY not A
DNA damage here is done by the drugs  if p53 cant apoptose...then it will keep replicatin...
its one of the common ways of resistance too
secondly...someone mentioned that only apoptotic one is p53 heree
what bout granzyme B
if inactivated...wont it also cause ANTIAPOPTOSIS?
but the prob is...it isnt inactivated by the cells... as its present in T cells which arent one of tumore cellls. chao
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