medocuk
IM-RES
Topics: 26
Posts: 1,466
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Acute alcohol intake induces CYP 450 where as chronic alcohol inhibits it.
Can some one please tell me why and how.
Thanks.
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| tompat
Forum Elite
Topics: 39
Posts: 345
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u got it wrong dude, it's the other way round.
acute inhibits 450.
but certainly dont know the molecular biology behind this
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| medocuk
IM-RES
Topics: 26
Posts: 1,466
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Hmm OK may be u r right, but I am looking for why this happens. I remember Goljan had explained in his lectures but now I can't seem to find it in my notes.
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| new_n_lost
Forum Hero
Topics: 674
Posts: 6,148
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the reason is that the enyzme is not that much regulated if the alcohol is ingested acutely. now if u r having a chronic usage of alcohol the enzyme gets up regulated and therefore u need large amounts of alcohol to saturate urself and get that buzz feeling.
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
Forum Hero
Topics: 674
Posts: 6,148
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P450 enzyme is the secondary method of Alcohol metabolism.
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| medocuk
IM-RES
Topics: 26
Posts: 1,466
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Thanks NNL. How are you doing. Thanks for dropping by.
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