forumdoctor
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Does IgM and IgE participate in antibody dependent cell mediated cytotoxicity?
thanks
Edited by forumdoctor on 09/03/07 - 10:36 AM
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| confusedoc
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IgG and IgE does.
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| spider
Forum Newbie
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IgA,IgG and IgE does. IgM is not a monomer
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| spider
Forum Newbie
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IgA, IgG and IgE does. IgM is not a monomer
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| macintosh
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Why not IgM. May you please explain?
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| garret
Forum Newbie
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as i know IgM exists as hexamer, a very big molecule that cannot diffuse across vessel, so it mainly stay in vessels to activate complements.
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| garret
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sorry... it should be pentamer... XD
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| isixju
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yah agree with garret
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| kukaus
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only IgG participates in ADCC, check chapter 7 of Kaplan Immunology "The generation of Humoral Effector mechanisms". Both IgG and IgM participate in compliment activation, and only IgG in opsonization ( along with C3b)
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| hitesh
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Also, IgE participates in ADCC of parasites
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| Jackofknives
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kukaus wrote:
only IgG participates in ADCC, check chapter 7 of Kaplan Immunology "The generation of Humoral Effector mechanisms". Both IgG and IgM participate in compliment activation, and only IgG in opsonization ( along with C3b)
I agree with this in that IgG is the only antibody that facilitates ADCC, but ADCC is not about opsonization, get your ADCC definition right. Most relevant for antiparacidal and anticancer actions.
Everything else said on this thread is BS
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| hitesh
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Jackofknives wrote:
I agree with this in that IgG is the only antibody that facilitates ADCC, but ADCC is not about opsonization, get your ADCC definition right. Most relevant for antiparacidal and anticancer actions.
Everything else said on this thread is BS
I dont see why you go around the forum calling threads "BS" and "officially declaring them irrelevant" 
When you disagree, just say so. If you cant, just move on..
It's all in bad taste. (More so, when you yourself dont have your facts right! )
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| Jackofknives
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hitesh wrote:Jackofknives wrote:
I agree with this in that IgG is the only antibody that facilitates ADCC, but ADCC is not about opsonization, get your ADCC definition right. Most relevant for antiparacidal and anticancer actions.
Everything else said on this thread is BS I dont see why you go around the forum calling threads "BS" and "officially declaring them irrelevant" When you disagree, just say so. If you cant, just move on.. It's all in bad taste. (More so, when you yourself dont have your facts right! )
I so need this as my daily dose of moral. That Ca2+ thread is irrelevant because the concentration needed to induce lethal bronchial spasm is much smaller than that needed for any observable cardiac effect.
What is ADCC? ADCC stands for antibody-dependent cell-mediated cytotoxicity. What does it mean? Antibodies binds antigens on foreign cell surface, immune cells bind the Fc segment and releases cytotoxic mediators to facilitate the killing of the targeted pathogen or foreign organism.
Which immune cell can do it? If you look it up in any comprehensive literature, the general congruent is that only natural killer cell can do it. I know Kaplan has a picture with macrophage, neutrophils etc etc on the ADCC picture but that’s BS.
What does natural killer cells have receptors for? IgG
Why can't IgE do it? IgE Fc segment has only high affinity for mastcells and mastcells do not contain cytotoxic granules.
Why can't IgA and IgM do it? If you ask this question, you are probably going to fail immune.
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| hitesh
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It's not about this post or the other! All I am saying is it doesnt hurt to be polite. But, whatever suits you! 
Coming to the discussion at hand, eosinophils cause ADCC of parasites by binding to the Fc part of IgE.
Do eosinophils have granules? you know what's probably gonna happen if you ask this question 
Edited by hitesh on 06/21/08 - 04:28 AM. Reason: typo
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| hitesh
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Coming to the cell types that can cause ADCC, again its not only NK cells. here's a few links that may help ya believe this BS  :
http://www.ajtmh.org/cgi/content/abstract/30/1/47
http://www.ncbi.nlm.nih.gov/pubmed/11589776
http://www.ingentaconnect.com/content/bsc/pimm/20...
http://www.ajtmh.org/cgi/content/abstract/30/1/47
http://www.blackwell-synergy.com/doi/abs/10.1111/...
http://www.ncbi.nlm.nih.gov/pubmed/11589776
http://en.wikipedia.org/wiki/Antibody-dependent_c...
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| Jackofknives
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I think you are right. I was taught that only NK cells play a significant role in ADCC but obviously thats not the case, supposedly because parasitic infections is not quite prevelant in this part of the world. But yea, I looked it up and paracites can be coated with IgE, which then initiate ADCC.
However, you got to admit, without me you would probably never bother to look it up and this thread would go to sh*t.
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| hitesh
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Jackofknives wrote: However, you got to admit, without me you would probably never bother to look it up and this thread would go to sh*t.
Well, thats true.. if you hadn't called my answer "BS", I actually would have sat back and let someone else correct you. I did get to learn something new as well
Not saying I appreciate it
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