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skinyballs
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An 18-year-old man is taken to the emergency room by his family when he develops very severe headache accompanied by high fever. On physical examination, the patient is incoherent and demonstrates nuchal rigidity. CSF shows gram-negative diplococci. When talking to the family, the physician learns that the patient has had 5 episodes of meningococcal meningitis in the past, the earliest being at age 6.Immunodeficiency related to impaired function of which of the following should be suspected?
A. B cells
B. Complement factors
C. Eosinophils
D. Neutrophils
E. T cells
Edited by new_n_lost on 09/03/07 - 01:11 PM. Reason: Ads Not Allowed in Posts
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| Ivonne
Find a way or make one
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(b)Complement factors
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| dr in trouble
Forum Guru
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Repeated infections d/t Encapsulated organisms are mainly d/t B cells def. Complement def can lead to meningococcemia but not meningitis.
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| Justice
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A. B cells
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| Ivonne
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1: Braz J Infect Dis. 2004 Aug;8(4):328-30. Epub 2004 Nov 19. Links
Deficiency of the eighth component of complement associated with recurrent meningococcal meningitis--case report and literature review.Rosa DD, Pasqualotto AC, de Quadros M, Prezzi SH.
Internal Medicine Department, Nossa Senhora da Conceição Hospital, Porto Alegre, Rio Grande do Sul, Brazil. ddrosa@terra.com.br
The authors report a case of deficiency of the eighth component of complement in a young adult with a history of three episodes of meningitis; one of them proved to be meningococcal. The literature was reviewed and meningitis due to Neisseria meningitidis strains causing disease in complement-deficient and complement-sufficient patients was demonstrated. Meningococcal disease may be the first manifestation of complement deficiency; screening for complement function must be considered for those with invasive meningococcal disease, with posterior evaluation of the components of the terminal pathway of complement.
PMID: 15565265 [PubMed - indexed for MEDLINE]
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| Ivonne
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http://www.emedicine.com/med/topic1444.htm
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| liliaeliz
Forum Elite
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B
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| liliaeliz
Forum Elite
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B
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| skinyballs
Forum Junior
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Are you sure?
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| Ivonne
Find a way or make one
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 Positive
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| elitoki
Forum Guru
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Posts: 508
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I think it is A
B cell deficiency that leads deficiency of memory cell (monocyte) to produce antibody.
skinyballs, what is the answer?
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| Justice
Forum Fanatic
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Well, in addition to this, antibodies are required for opsonization of encapsulated microorganisms
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| skinyballs
Forum Junior
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The answer is B.
The site I listed has more questions on the right side.
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| neuroblastoma
Forum Guru
Topics: 101
Posts: 1,023
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B
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| amkhit
Forum Newbie
Topics: 4
Posts: 32
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Complement deficiency due to defect in opsonisation.There is a particular observation I could not overlook and hence will not stop to comment. One of the forum SENIORS Ivonne explains his answer with a case report. In this era of evidence based medicine , case reports are often published to report unusual phenomenon to prompt further analysis and studies , so even though the answer may be correct , relience on case reports for exam information may be desisted. What pains me more is that a forum senior would resort to such immature behavior .Clearly this so called senior ( who is senior only as per the number of posts and comments he posts on the site.)has no clue about Evidence based medicine and hence the real world and hence i request him review his response before he posts. Being a senior, his opinion is bound to be revered and regarded by many as correct. Seniors and elites should be responsible and should not misguide young anxious minds.
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| me007
Forum Guru
Topics: 72
Posts: 803
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b.
i remember tons of similar qs from step 1.
Immuno as well as path pointed on C5-C8 deficiency as cause of recurrent Neisseria infections.
eg.
http://www.prep4usmle.com/forum/comments.php?id=3...
or
http://www.prep4usmle.com/forum/comments.php?id=2...
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