Prep for USMLEPrep for USMLE Forum
   Forum    Step 1  Step 2 CK Step 2 CS Step 3  Match  IMGs Resources Search






Previous Topic | Next Topic  alveolar gas equation 




 
Kaplan Qbank USMLE



Author6 Posts
  #1

Alveolar gas equation:
PAO2=(Patm-47)xFO2 - PACO2/R

I know what R is (respiratory exchange ratio) but I don't understant WHY the equation needs it. I meen alveolar O2 pressure should simply be the inspired O2 pressure minus the CO2 pressure (allready found in the alveola). Why the correction factor?

  #2

See the original equation is: (alvPO2=inspiredPO2 – dec. in PO2)

We are able to replace the dec. in PO2 by the inc. in PCO2(40-0=40) only when R=1 so that the change in oxygen conc. in the alveoli equals the change in CO2 conc.(in other words the change in alv. PO2 equals the change in alv. PCO2), but when R≠1 then the equation is no longer right and we must include R in it.

I hope this makes sense.smiling face


  #3

It makes sense. I thought at it but I dismissed it because I thought that there is no inc. in PCO2 since it always stays around 40 and never goes down to 0. So actually there is no 40-0. That's in fact my problem shaking head...
But I admit that your explanation must be it nod

  #4

You are right, the air in the respiratory zone remains stable, but what I meant is the change in PO2 and PCO2 of the inspired air as it moves from the conducting zone to the respiratory zone and undergoes gas exchange,

PCO2 inc. from 0 in the airways to 40 in the alveoli (inc. 40 mmHg) and PO2 dec. from 150 in the airways to 100 in the alveoli (dec.50 mmHg)

Now see the ratio between (inc. in PCO2/dec. in PO2) = 40/50=0.8, that's normal R (40 mmHg PCO2 in exchange of 50 mmHg PO2)

remember the original equation (alv.PO2 = inspired PO2 – dec. in PO2)
we can simply replace the dec. in PO2 by the inc. in PCO2(=PCO2)/R

GL
smiling face

  #5

Thank younod!

  #6

I am sorry but I differ with this theory...

R isnt a correction factor first of all...
seconldy....
R is an experimentally calculated coefficent which means

1 mol of Oxygen produces 0.8 mol of CO2
so when we are equating the whole thing... we have to divide the PCO2 by this factor... so to get an equimolar value ...
tnx







You don't have permission to post.




Login or Register to post messages in this topic





















Contact | Leaders | Disclaimer | Privacy

Copyright @ Prep for USMLE. All rights reserved.