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Kaplan Qbank USMLE



Author9 Posts
  #1

A 42-year-old female presents with a recent onset of fatigue, malaise, constipation, and a 12-pound weight gain. On examination, her thyroid is firm and enlarged.

What laboratory test is most likely to confirm the expected diagnosis?

A. Antithyroid antibodies
B. Serum thyroid-stimulating hormone (TSH) measurement
C. Serum thyroxine (T4) measurement
D. Serum triiodothyronine (T3) measurement
E. T3 resin uptake



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  #2

Hypothyroidism------------>chk TSH first---------->B

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  #3

TSH is a more sensitive indicator of primaryhypothyrodism than the decrease in T4. Because the total circulating T4 represents the bound T4 also which is in active.

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  #4

Confirm?-i'd say D.

  #5

MT what makes you sure that they already checked TSH ?!

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  #6

i will go for b as well.


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  #7

b

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  #8

Aashi wrote:
Hypothyroidism------------>chk TSH first---------->B

nodnod

___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."

  #9

The correct answer is B.

The patient's presentation is consistent with hypothyroidism. Serum thyroid-stimulating hormone (TSH) measurement (choice B) is most likely to confirm the empiric diagnosis.

TSH levels usually rise above normal before serum thyroxine (T4; choice C) and serum triiodothyronine (T3; choice D) levels do, even in mild cases of hypothyroidism. Therefore, TSH measurement would be the most accurate test to determine the presence of hypothyroidism regardless of the severity.

A high titer of antithyroid antibodies (choice A) is characteristic of chronic thyroiditis, which is the most common cause of hypothyroidism. However, detection of these antibodies would not indicate if hypothyroidism was present.

T3 resin uptake (choice E) measurement is not an accurate test of thyroid function; it is primarily used to exclude various abnormalities in the thyroid-hormone binding proteins.



___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."







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