amritt786
Forum Senior
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which organ has highest km for glucose?
brain
muscle
pancres
liver
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| edie
I can, and I will.
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Liver?
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| amritt786
Forum Senior
Topics: 26
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i think its pancreas because it has to sec insulin . so insulin is secreted when every organ as its glucose. and brain has lowest sothat it can extract every glucose from circulation. correct me if i am wrong
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| Ujk
Forum Guru
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Pancreas
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| edie
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Still not sure:
"Liver and pancreatic b cells have a distinct glucose transporter with a high Km, around 15-20 mM. In these cells, then, the amount of incoming glucose is pretty much proportional to the amount of glucose in the blood. This allows the b cells to monitor blood glucose levels directly, and thereby regulate insulin secretion. It also insures that glucose is taken up rapidly by the liver only when it is abundant; in the fasting state, more glucose is delivered to other tissues (particularly the brain)." From http://cmgm.stanford.edu/biochem200/regulation/
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