crista
Forum Guru
Topics: 121
Posts: 408
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The mtDNA is inherited from mother so how it;s posible to have heteroplasmicity in the body cells, I mean normal and affected mtDNA?
May be I didn't understand the term of heteroplasmicity...
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| asmi
Forum Hero
Topics: 1043
Posts: 4,609
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it means that normal + mutated mitochondrial DNA molecules are present in the same person .
As the no. of mutated molecules increases,the severity of disease increases .
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| crista
Forum Guru
Topics: 121
Posts: 408
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if the child inherited mutated mtDNA, which is the origin of normal mtDNA?
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| krsma
Forum Elite
Topics: 40
Posts: 227
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I think the correct term is Heteroplasmy -->
Is heteroplasmy inherited or does it come about from mutations in mitochondial DNA during mitotic divisions? I'm not sure
yes, it's true that we get our mtDNA from MOM, but we can also develop our own mutations in our mitochondrial dna later in life when for example a whole bunch of mitochondria undergo mitosis, and somewhere an error occurs, leading to us having some normal mitochondrion and some mutated. (this intention of mutation may not have came from MOM, or it may have, who knows")
I don't know if i'm making any sense, let me know what you think!
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| crista
Forum Guru
Topics: 121
Posts: 408
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may be some of the mt DNA is normal because an ovocyte has more than 1 mitochondrion...
or you are right...
tx anyway.
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| Malaysian
Forum Guru
Topics: 28
Posts: 778
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I don't know whose right but whatever it is I hope they don't ask these sort of questions in the USMLE!!!
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| Ritalin
Forum Newbie
Topics: 3
Posts: 30
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Heteroplasmy has been proposed as a marker of aging. Remember that mitochondrial DNA lacks of the repair mechanisms that exist in the nucleus, hence its vulnerability.
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