mytime
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edie wrote:
Which tumor suppressor gene is is considered the "guardian of the genome" and why? What multiple-tumor syndrome is associated with this gene?
p53. Produces 'bax protein" which watches over the bcl gene "Youth of fountain" and says stay in ur place.........so gaurds any genetic dfects from going into synthesis phase of cell cycle........CyclinD/E kinase dependent first check point!
Li Fraumeni's syndrome. the whole 8 miles.............let nNL write the details i go finish up!!!!!!!!!!
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| edie
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You are My-T sharp, MT!!! To add, bax initiates apoptosis. Li Fraumeni syndrome where one family has individual manifestations of different cancers.
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| edie
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What are some viruses that can cause cancer? Bacteria? Parasites?
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| yuna
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| mytime
Kick my butt!
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WHAT SHARP My brain has beeeeeeeeeeeeen in the slaughter maybe that's y!
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| new_n_lost
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mytime wrote: p53. Produces 'bax protein" which watches over the bcl gene "Youth of fountain" and says stay in ur place.........so gaurds any genetic dfects from going into synthesis phase of cell cycle........CyclinD/E kinase dependent first check point! Li Fraumeni's syndrome. the whole 8 miles.............let nNL write the details i go finish up!!!!!!!!!!
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| mytime
Kick my butt!
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edie wrote:
What are some viruses that can cause cancer? Bacteria? Parasites?
HPV- Anal and cervucal Ca
EBV- we just did.
HTLV-1 Adult T-cell leukemia
HTLV-2 I think, Hairy cell
HBV/HCV _ Hepatocellular by the way the only preventable Ca.
HHV-8 KAposi sarcoma
H.pylori- Gastric Ca I'm lost now........burnt out.
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| po
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HBV/HCV _ How do these cause cancer?
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| yuna
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EBV 1 more nasopharyngeal Carcinoma
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| mytime
Kick my butt!
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yea.............. hey what abt the parasites? And more bacterias? 
po wrote:
HBV/HCV _ How do these cause cancer?
THAT HEHEHEHE I forget...........too much pressure! 
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| edie
I can, and I will.
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The only bacteria I can think of off the bat is H. pylori. Fungus that causes cancer is that one from moldy grain, Aspergillus with the aflatoxin. A type of Schistosomas causes bladder cancer, and there are a couple of parasites Papi mentions that cause bile duct cancer.
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| edie
I can, and I will.
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For how Hep B/C causes cancer, it might deal with the plastis that occurs during the inflammatory and subsequent cirrhotic processes. The liver in trying to heal itself, may set off cells that don't want to just repair damage and die--they want to go on forever and ever!
Now, I am just guessing about this, can someone shed some light?
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| edie
I can, and I will.
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Nice pic Yuna Sums it all up, thank you 
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| anmelie
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Mytime and I were searching out stuff for this post, so this is what we got! Hope it helps.
J Clin Virol. 2005 Dec;34 Suppl 1:S75-8.
HBV induced carcinogenesis.
Cougot D, Neuveut C, Buendia MA.
Oncogenesis and Molecular Virology Unit, INSERM U579, Institut Pasteur, Paris, France.
Hepatocellular carcinoma (HCC) is one of the rare human neoplasms associated with viral infections. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most important etiological factors of HCC, accounting for more than 70% of cases worldwide. The risk of HCC development is greatly increased in chronic viral carriers exposed to other recognized risk factors, including exposure to aflatoxin B1, alcoholic cirrhosis and diabetes. The importance of HBV genotypes and precore or core promoter mutants remains incompletely understood. The role of HBV in tumour formation appears to be complex and may involve both direct and indirect mechanisms. Integration of HBV DNA into the host genome occurs at early steps of clonal tumour expansion, and it has been shown to induce direct insertional mutagenesis of diverse cancer-related genes in a number of cases. Chronic liver inflammation and hepatic regeneration induced by cellular immune responses may favour the accumulation of genetic alterations in infected hepatocytes. Prolonged expression of the viral regulatory protein HBx and the large envelope protein LHBs may contribute in deregulating the cellular transcription program and proliferation control, and sensitize liver cells to carcinogenic factors. Recent genetic studies have provided insight into the mechanisms underlying viral-associated hepatocarcinogenesis. It has been shown that the rate of chromosomal alterations is significantly increased in HBV-related tumours compared with tumours associated with other risk factors. HBV might therefore play a role in enhancing genomic instability. Inactivation of p53 by mutations and regional allelic deletions is found more frequently in tumours associated with HBV infection. By contrast, HBV related tumours harbour a low rate of beta-catenin mutations. Together, these data strongly support the notion that chronic HBV infection might trigger specific oncogenic pathways, thus playing a role beyond stimulation of host immune responses and chronic necro-inflammatory liver disease.
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| anmelie
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Other parasites we came up with-
Schistosoma haematobium- bladder CA
Clonorchis sinensis- hepatobiliary CA, cholangicarcinoma
Anyone else come up with anything?
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| edie
I can, and I will.
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THANK YOU Ammelie and MyTime!!!!! Good work  So basically, those viruses "sensitize liver cells to carciogenic factors". I shall never forget this
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| edie
I can, and I will.
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anmelie wrote:
Other parasites we came up with-
Schistosoma haematobium- bladder CA
Clonorchis sinensis- hepatobiliary CA, cholangicarcinoma
Anyone else come up with anything?
Yes, in RR Path, p146, Opisthorcis viverrini - cholangiocaricnoma of the bile ducts
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| mytime
Kick my butt!
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anmelie wrote:
Other parasites we came up with-
Schistosoma haematobium- bladder CA
Clonorchis sinensis- hepatobiliary CA, cholangicarcinoma
Anyone else come up with anything?
My baby!!!!!!!!!! :MWAH: tnx.
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| edie
I can, and I will.
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What serum marker(s) can we find with hepatocellular carcinoma?
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| medocuk
IM-RES
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Raised Alpha feto protiens.
which is the only carcinoma in the body that can be prevented by a vaccine. * cheeky question I know*
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| edie
I can, and I will.
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Yes, Med What else raises AFP besides hepatocellular carcinoma? What can lower it?
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| edie
I can, and I will.
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medocuk wrote:
Raised Alpha feto protiens.
which is the only carcinoma in the body that can be prevented by a vaccine. * cheeky question I know*
Not so fast there, Med...we can now prevent squamous cell carcinoma of cervix with a vaccine, Gardisil (sp?)
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| medocuk
IM-RES
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Any embryonal cell tumor can cause the rise in Alpha feto protiens..eg Yolk sac tumor of the testes.
It is decreased in Down's syndrome.
Oh and I didnt know! Thanks..
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| yoga
usmlelogy professor
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edie wrote:
What serum marker(s) can we find with hepatocellular carcinoma?
hepatitis vaccine=> hepatocellular carcinoma
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| acintya
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Thanks for the reinforcement all of you!!
by the way, AFP increased also in neural tube defects
And H. pylori is the only bacteria associated with cancer.
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