edie
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Just wanted to throw some HY stuff out there. Can you tell me which disease goes with the translocation?
a. t(14:18)
b. t(8:14)
c. t(15:17)
d. t(9:22)
e. t(11:14)
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| yuna
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Thanks Edie, they are so important in the test.
edie wrote:
Just wanted to throw some HY stuff out there. Can you tell me which disease goes with the translocation?
a. t(14:18)
b. t(8:14)
c. t(15:17)
d. t(9:22)
e. t(11:14)
1. which one causes activating the tyrosine kinase?
2. Which one has starry sky morphology
3. Which one is due mostly to EBV infection
4. Which one has relationship with retinoic acid
5. Which one has 2 forms of manifestation
Some HY facts
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| edie
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Thanks for the correlates, Yuna  
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| edie
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OK, I'll start,
1. d. t(9:22)--> CML; chr 22 is Philadelphia chromosome. Proto-oncogene is ABL (Goljan calls it "Ah-blah") and it has tyrosine kinase activity.
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| keepgoing
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2.t(8:14)-->burkitt's lymphoma-->c-myc oncogene-->LN pattern-->starry sky)-->associated with EBV in 5-15% cases
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| yuna
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When a pt working as a crew in a construction site, has manifestation of restrictive lung diseases, which one you should ask (sorry I post here cause at beginning I think about mesothelioma... )
A. Brick dust
B. Abestos
C. Plaster
D. Smoking
E. Shipyard work
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| new_n_lost
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a. t(14:18) >> Follicular Lymphoma BCL overexpression
b. t(8:14) >> Burkitt's Lymphoma myc
c. t(15:17) >> AML (M3 Acute Promyelocytic) Fusion of RAR gene for Retinoic acid
d. t(9:22) >> CML ( 22 is Philadelphia Chromosome) abl translocation
e. t(11:14) >> Mantle Cell Lymphoma BCL gene dysregulation.
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| edie
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yuna wrote:When a pt working as a crew in a construction site, has manifestation of restrictive lung diseases, which one you should ask (sorry I post here cause at beginning I think about mesothelioma... ) A. Brick dust--> bricklayers B. Abestos--> roofers C. Plaster--> construction workers, artisans D. Smoking --> anyone over 50 years with long Hx of smoking? E. Shipyard work--> can also include railworkers?
Gross specimen of lung has thick outer layer of tissue like "icing on a cake" --Goljan 
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| edie
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NNL, you got em all
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| edie
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yuna wrote:
5. Which one has 2 forms of manifestation
Would that be Burkitt's--> 1. abdominal and 2. mandibular/craniofacial, the latter unique to Africa?
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| mytime
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Yuna I'd go for B.
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| mytime
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yuna wrote:
Thanks Edie, they are so important in the test.
1. which one causes activating the tyrosine kinase? CML
2. Which one has starry sky morphology Burkitt's
3. Which one is due mostly to EBV infection Burkitt's
4. Which one has relationship with retinoic acid M# AML
5. Which one has 2 forms of manifestation U got that EDs!
Some HY facts
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| mytime
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EBV- follicular Lymphoma, actually that sud b emore common, i think.
Burkitt's
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| edie
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Why do we give retinoic acid in M3 AML?
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| mytime
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edie wrote:
Why do we give retinoic acid in M3 AML?
It induces remission. Gene inolved PML/rar (retinoic acid receptor)alpha.
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| mytime
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edie wrote:
Why do we give retinoic acid in M3 AML?
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| edie
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Go Mytime!!! Induces remission be inducing maturation of the cells.
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| yuna
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Great discussion. I wonder why I didn't know this earlier
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| edie
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Which tumor suppressor gene is is considered the "guardian of the genome" and why? What multiple-tumor syndrome is associated with this gene?
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| yuna
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I chose brick dust, thinking of Silicosis, I think I got that wrong
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| new_n_lost
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edie wrote:
Why do we give retinoic acid in M3 AML?
For the Early Maturation of the Tumor Cells the Tranlocation of the RAR gene casues the retinoic acid receptor blockade. This blockade further blocks the Myeloid Cell differentiation. This Block is overcome by giving all-tran-retinoic acid which induces differentiation in the neoplastic promyelocytic cells into neutrophils which immediately die. Thus death by Differentiation causes a remission in disease.
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| edie
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yuna wrote:
I chose brick dust, thinking of Silicosis, I think I got that wrong
Isn't silicosis precursor to mesothelioma?
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| edie
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I am seeing that abestosis is most common for mesothelioma.
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| yuna
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no, edie, the Qs doesn't ask about mesothelia, and has no clue on it, just the career and the restrictive lung disease
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| edie
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Ah, the pnemo-osis, what ever, you guys know what I mean, diseases. got it
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