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asmi
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03/14/04 - 01:51 PM             #1

Where is the defect in hereditary nonpolyposis coli ?

Colombia
Forum Guru

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03/14/04 - 02:06 PM             #2

HNPCC gene which codes for a DNA repair enzyme. Acoount for 2% of all colon cancer.

asmi
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03/14/04 - 02:13 PM             #3

:arrow: mutation involving hMSH2 and hMLH 1 .
:arrow: there occurs " microsatellite instability" ( DINUCLEOTIDE REPEAT INSTABILITY)

Colombia
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03/14/04 - 02:17 PM             #4

Thanks asmi.
asmi you are my idol. Thanks for being active ,nice and friendly. I wish the best in your exam because you deseve it.

asmi
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Topics: 1043
Posts: 4,609
03/14/04 - 02:19 PM             #5

Thanks columbia,

I wish you the same....

krsma
Forum Elite

Topics: 40
Posts: 227
03/16/04 - 04:23 AM             #6

Also guys, try to remember that this is also called "Lynch syndrome", nbme will change the names around!!!

and has increased risk for colon, ovarian, and endometrial cancer.

usmleasr
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03/16/04 - 05:46 AM             #7

thanks







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