keepgoing
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hmm B12 if-->methymalonic acid in urine..to differentaite between folate or B12 cause..
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| keepgoing
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and folate deficiency most common in alcoholics
Edited by keepgoing on 08/21/07 - 12:51 AM
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| edie
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Cool, KG! So you checked the urine, there's no methylmalonic acid, no sign of mental abnorm...how do you treat?
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| edie
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And, what is the mech of folate def in alcoholics?
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| hope4dabest
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by intrinsic factor deficency test....forgot how exactly it worked...
B12 dependent enzymes--methymalonly coenzyme and homocytine transferase
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| edie
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yes, you give IF and look for methymalonic acid in pee. If pos, then problem w/IF, due to...what?
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| hope4dabest
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b12
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| edie
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Think about possible causes of no intrinsic factor being produced. Recall that it is needed to absorb the B12. Hint: where is IF made?
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| hope4dabest
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py parietal cells of stomach..atrophic gastritis..what r we geting at???
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| edie
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You got it! It's atrophic gastritis  Another cause would be gastrectomy. Another would be antibodies against the parietal cells.
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| medocuk
IM-RES
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Wow totally loved the discussion here. Now this is what I call fun.
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| edie
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Right!! This is what keeps me up late  . Pls add a q or two 
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| keepgoing
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okay.an easy one..
A young athelete,whose diet conists of mainly raw eggs,what is he dificient in and why?
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| hope4dabest
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deficirnt in biotin.... ..y???? so deficient in carboxylase enzymes
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| medocuk
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Here is another one. How does chronic pancreatitis lead to Vit b12 def.
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| hope4dabest
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in chronic pancreatitis the pancreatic enzymes will br affected. B12 binds to R protein and this R protein cobalamin complex which is broken down by pancreatic enzymes will be affected so B12 deficency
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| edie
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Can anyone tell me why we use vitamin E to treat abetalipoproteinemia?
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| hope4dabest
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just a guess, m not sure....
In a abetalipoproteinemia there is low to absent apo B 100..... Vit E prevents oxidation of LDL... we know oxidation of LDL affects by damaging apo B 100 which cannot be now recognized by LDL receptors so as in abetalipoproteinemia there is low apo 100 so vitamin E prevents the rest of apo 100 from being oxidised......
i didnt even know that Vit E is used to TREAT ABETALIPOPROTEINEMIA...i just knew that it has some role in preventing atheroslserosis by preventing oxidation...
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| mikky
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urine figlu increased in folate deficiency nd in b12 def urine methyl melanoic acid increases
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| edie
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hope4dabest wrote:
just a guess, m not sure....
In a abetalipoproteinemia there is low to absent apo B 100..... Vit E prevents oxidation of LDL... we know oxidation of LDL affects by damaging apo B 100 which cannot be now recognized by LDL receptors so as in abetalipoproteinemia there is low apo 100 so vitamin E prevents the rest of apo 100 from being oxidised......
i didnt even know that Vit E is used to TREAT ABETALIPOPROTEINEMIA...i just knew that it has some role in preventing atheroslserosis by preventing oxidation...
Abetalipoproteinemia seems to mess up aborption of all fat-soluble vits, bur moreso with vit E. As to the pathophysiology and therapy, I think you are on the right track. If anyone has anything to add, pls do so.
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| edie
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Another q:
Male 23 y.o. w/recurrent pulmonary infections and finger clubbing shows extensive exocrine gland atrophy and fibrosis. Pancreatic ducts are lined with squamous epithelium with areas of keritinization, which is related to a deficiency of:
a. riboflavin
b. vit A
c. vit D
d. vit E
e. vit K
f. vit C
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| keepgoing
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vit a??
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| edie
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Yes, KeepGoing, it's vit A. Normal vit A levels regulate orderly differentiation of epithelia, including mucus-secreting columnar epithelium. Deficiency of vit A causes the cells to undergo squamous metaplasia.
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