sam_step1
Forum Junior
Topics: 23
Posts: 38
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Hi All,
Can one make clear what type of necrosis goes in acute & chronic pancreatitis? liquifative or fat or both.
Thanks.
~Sam.
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| hope4dabest
Forum Elite
Topics: 19
Posts: 438
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i guess it should be liquifactive coz of enzymatic process in both chronic and acute. ..
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| hope4dabest
Forum Elite
Topics: 19
Posts: 438
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Acute pancreatitis leads to death and inflammation in the pancreas. Three types of necrosis may be distinguished: (1) interstitial tissue necrosis, which subsequently may also involve acinar and ductal cells, (2) ductal necrosis, and (3) acinar necrosis. The first type of necrosis is autodigestive in nature and is typical of the most common forms of acute pancreatitis, which are associated with alcohol, bile duct disease, metabolic conditions, and other rare factors. Clinically, these types of pancreatitis may be either mild or severe. The mild form is also known as edematous pancreatitis, because there is edematous swelling of the pancreas combined with tiny foci of interstitial (fat) necrosis. Severe or necrotizing pancreatitis shows large areas of often hemorrhagic necrosis of the pancreatic and particularly the peripancreatic tissue. The ductal type of necrosis is rare and may be seen in pancreatitis associated with prolonged circulatory failure. The acinar type of necrosis is caused by infectious agents. Complications of acute pancreatitis, such as pseudocyst, bleeding, and infection, determine the course of the disease.
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| hope4dabest
Forum Elite
Topics: 19
Posts: 438
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i got this info on net
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| edie
I can, and I will.
Topics: 26
Posts: 1,201
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Enzymatic and fat for pancreas. Liquefactive, for brain and gangrenous tissue, from Goljan 
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| hope4dabest
Forum Elite
Topics: 19
Posts: 438
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ok..but kaplan says liquifactive for pancreas too...but i guess should go with goljan ..
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| Tiff
Forum Guru
Topics: 55
Posts: 581
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This is fat necrosis of the pancreas. Cellular injury to the pancreatic acini leads to release of powerful enzymes which damage fat by the production of soaps, and these appear grossly as the soft, chalky white areas seen here on the cut surfaces.
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