Primary Aldosteronism

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Primary Aldosteronism

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new_n_lost
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08/16/07 - 09:02 PM

Why Doesnt Primary Aldosteronism have Edema ??

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new_n_lost
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08/16/07 - 09:09 PM

As the Aldosterone Secretion increases the Renin Secretion dec which slows development of Edema now the increased Extracellular volume is now countered by ANP. As the Atria r stretched the ANP is Released and it counters all the effects of Aldosterone.

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mytime
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08/16/07 - 09:09 PM

Hey sudn't be the simple fact that water follows Na+? Which in this case is out in the pee.

K+ increases within the cell, NA+ moves out and water follows!

mytime
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08/16/07 - 09:10 PM

Hey we posted at the same time!!!!!!!!!! GREAT MIND AND ALL! SAME ans. our own ways...... grin

mytime
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08/16/07 - 09:11 PM

OOYE NNL Love the xtension to ur signature plz. delete the first part the second is so u!!!!!!!!!!! grin

P4a99
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08/16/07 - 09:14 PM

Thanks NNL smiling face

( i got your answer ), but sorry MT what did you mean? this is hyperaldosteronism.

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hope4dabest
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08/16/07 - 10:13 PM

exactly!! this is hyperaldo.....i guess my is confusing it with something

mytime
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08/17/07 - 06:58 AM

[left]LAck of sleep and too much excitement! U got it I was thinking of Addison's hahahahahahahahaah!!!!!!!!!!!!!!!!!! grin

And for that am correct. If u believe Iwent to sleep rt. after with book on my lap! sticking out tongue

[/left]

efti
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08/18/07 - 09:55 PM

The other reason for which ppt with Conn's syndrome wouldn't have edema is Na escape phenomenon.

P4a99
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08/19/07 - 09:54 PM

#10

We knew it was because of the escape phenomena ... but he was explaining its mechanism.

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efti
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08/22/07 - 12:08 AM

#11

Well, the Na escape phenomenon is MAINLY caused by 'pressure diuresis' not ANP (ANP contributes a little bit to that process), but since 'you knew' I am sorry for putting my 2 cents... And as a matter of fact ANP doesn't counteract all the aldosterone effects... I hope this is obvious to you as well.
All the best.
Aloha smiling face

efti
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08/22/07 - 12:24 AM

#12

The truth is that the patient with primary hyperaldosteronism in the end will present with hypernatremia again smiling face

Na escape phenomenon augments K loss (which your pt is already loosing due to high level of aldosterone). Severe hypokalemia causes decreased ADH sensitivity in collecting ducts – which in turn causes decreased water reabsorption which leads to hypernatremia.
Another abnormality in primary hyperaldosteronism will be tetanus-like muscle contractions also indirectly caused by K & H loss. As you know hypokalemic alkalosis causes albumin COOH groups disociation into COO- and H+ ; COO- react with plasma Ca decreasing the free plasma Ca and in that way bringing the resting potential closer to the treshold...
Ok? I don't really think that they would ask for all that on Step 1.. however... the most important thing is to always suspect primary hyperaldosteronism in the patients with HT and hypokalemia. Period.
Aloha smiling face

new_n_lost
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08/22/07 - 12:43 AM

#13

efti wrote:
Well, the Na escape phenomenon is MAINLY caused by 'pressure diuresis' not ANP (ANP contributes a little bit to that process), but since 'you knew' I am sorry for putting my 2 cents... And as a matter of fact ANP doesn't counteract all the aldosterone effects... I hope this is obvious to you as well.
All the best.
Aloha smiling face

Do U have a reference to that Statement cos i found it different in OTM and Emedicine. Can u share the reference if u have one, ??

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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."

efti
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08/22/07 - 12:58 AM

#14

Hey.
If I would be looking for any reliable answer on-line my choice would be New England Journal of Medicine (NEJM).

efti
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08/22/07 - 01:07 AM

#15

You can find good article on Primary Hyperaldosteronism in Clinical Endocrinology
Vol. 45 Issue 1 Page 47 July 1996

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