cirus
Forum Guru
Topics: 108
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Can somone plz tell me how to differentiate between different types of acute myeloid leukemia, is this even imp or its just UW, all i know:
in case of DIC--->its M3
In case of CNS manifest ( encephalitis like)---> its M4,5
but how to differentiate monocytic from myeloid with maturation from myeloid without maturtion??
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| cirus
Forum Guru
Topics: 108
Posts: 740
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anyone
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| brutus25
Forum Junior
Topics: 13
Posts: 62
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Got this one , since I was studying for S1.
No ideea what you`re really looking for.
Hope it helps , in which case please let me know - as I wouldn`t like to learn this bull and find out afterwads that I shouldn`t have learnt it.For sure , I didn`t know it for S1 , and neither did I needed it.
M1 (myelocytic) without differentiation. A substantial proportion of cells are myeloperoxidase-positive; few cells mature beyond the myeloblast stage.
M2 (AMLwith maturation) > 30% blasts, with more than 50% of the blasts being myeloblasts and promyelocytes. Mature forms are seen as well. Eosinophils may be heavy in some cases.
M3 (APML) > 30% blasts. The majority of cells have a promyelocytic appearance with kidney-shaed nuclei. Auer rods are usually seen in the cytoplasm.
M4 (Myelomonocytic) >30% blasts, with promonocytes and monocytes accounting for more than 20% of the bone marrow aspirate.
M5 (Monocytic) > 30% blasts; the granulocyte component is less than 10% of marrow cells. The monocytes can be detected cytochemically with the fluoride-sensitive esterase reaction
M6 >30% blasts, of which more than 50% are erythroblasts
M7 (Megakaryocytic) In this condition, blasts react with antiplatelet antibodies.
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| cirus
Forum Guru
Topics: 108
Posts: 740
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[left]Thanks man, appreciate it.. [/left]
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