Bela
Forum Guru
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Pt has a mitral valve replacement. Was placed on anticoagulants and prophylactic antibiotics. Some days later develops sharply demarcated rash on thighs, which later develop into hemorrhagic bullaes. Drug? By what mechanism?
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| asmi
Forum Hero
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warfarin....acts by inhibiting gamma carboxylation of vitamin K dep . factors 2,7,9,10 . I think its via decreased protein C levels ..that the pt developed rash and hemorrhagic bullae.
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| Bela
Forum Guru
Topics: 76
Posts: 412
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Very good! 
Yes, I read that we should look for this day 3-10?? of warfarin tx.
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