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asmi
Forum Hero Topics: 1049 Posts: 4620 |
what is the role of shine dalgarno sequence in prokaryotes /5' MeG cap in eukaryotes ?
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black_tulip
| Forum Senior Topics: 14 Posts: 95
this sequence is an important rRNA binding site for efficient translation. The protein translation will be remarkably decreased without this sequence.
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step1taker
| Forum Senior Topics: 2 Posts: 104
"asmi" wrote: what is the role of shine dalgarno sequence in prokaryotes /5' MeG cap in eukaryotes ? "SHINE DALGARNO sequence (only in prokaryotes) is found in the untranslated region (UTR), upstream of initial codon(AUG) of @ gene transcribed."(KaplanBiochem)  In short-it's an untranslated gene found in the mRNA spcifically just before the start point of the coding region.My mnemonic for that is: the sun SHINES BEFORE prokaryotes START :wink: ------------------------ On the other hand, 5' cap due to a 7-MethylGUANOSINE (only in EUK) is a post-translational modification of mRNA. its purpose it for ribosome binding and protection for mRNA degradation. Other post-translational modific of mRNA is 3' tail (Poly A) to protect messenger from degradation and aids in transport to cytoplasm.some mrnAs (like histone mrnas)have no poly A tails., Lastly Intons are spliced just before mRNA goes to cytoplasm. In short just imagine the mRNA is like a sperm inside the nucleus that puts on a cap(5') for protection and binding, and tail(3') for motility & splices unneseccary accessories (introns ) before going out to the cytoplasm. :wink: I hope this helps :wink: Im having a hard time understanding molec bio too.But im TRYING to love it for step1. :lol: heck!
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asmi
| Forum Hero Topics: 1049 Posts: 4620
excellent explanation.. keep it up :idea: Thanks for nemonic
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