asmi
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i will name few...
epithelium of fallopian tube , trachea ..
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| Sakaki-
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Vas deferens, bronchi, bronchioles, epididymis, ependymal cells (in the ventricles), olfactory epithelium, larynx, false vocal cords.
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| Bela
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"Cherry Lav" wrote:
Vas deferens, bronchi, bronchioles, epididymis, ependymal cells (in the ventricles), olfactory epithelium, larynx, false vocal cords.
Hmmmm, I thought vas deferens, epididymis, olfactory epithelium have STEREOCILIA, which are different from cilia.
Cilia/Flagella are microtubules made up of tubulin with a 9:2 arrangement and dynein arms, whereas Villi/Stereocilia are microfilaments made up of actin.
Can anyone confirm/oppose what I am saying? :?
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| Sakaki-
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Yeah--you're right, Bela, about the epididymis and the vas deferens possessing stereocilia, though I'm still quite sure that the olfactory epithelium has cilia.
My mistake.
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| Bela
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You're right about olfactory. It's just that my brain is stuck in NREM sleep even though I am up...it thinks one thing and says another 
What I wanted to say is the hair cells in middle ear, not olfactory.
So, epididumus, vas deferens, hair cells in inner ear have stereocilia
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| asmi
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Name the genetic disease with ciliary function defect ?
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| Colombia
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Kartagener syndrome= sinusitis+situs inversus +sterility.
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| asmi
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correct
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| bluestar
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anybody can explain why sterility occurs in Kartagener syn?
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| mash
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bcoz motility of the sperm is lost( which is due to flagellum)
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| santaclara
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yes mash u r right.
but can anybody tell me (is cilia not present in intestine?)
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| rida
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I don't think so santaclara, because thats where you have microvilli for increase surface area for better absorption. Cilia usually functions to remove toxins but I could be wrong, please correct me if i am???
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| bluestar
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I agree with rida. Also continue with my question of Kartagener syndrom: what's the relation between flagella and cilia? cuz we all know that Kartagener syn is immotile cilia syndrome then what part does flagella play here?
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| mash
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flagella and cilia ve same microstructure--- 9+2 microtubules.
peripheral doublets r fused so dat they share a common tubule n form 2 subunits A& B
movement of cilia / flagella is due to dynein arm attached to A subtubule. The arms bind to ATP & rearrange themselves so dat a binding site fr B subtubule in the tip of arm is exposed. B tubule interacts with the binding site causing the arm to snap back n movement to occur .
flagella r longer than cilia but ve same microst.
single flagellum provides motility in the sperm
Kartageners syndrome is absent or aberrant dynein arms. pts present with ch sinusitis, bronchiectasis and infertility
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| bluestar
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thank you, mash for your clarification. I didn't know cilia and flagella are the same. I checked my note about their relative length, cilia could be LONGER than flagella. but this explains sterility very well.
Another question, in case cilia of oviduct is defective in Kartagener syn, could that bring any severe outcome as well? I am thinking of ectopic pregnancy, cuz the function of cilia of oviduct is to bring fertilized egg to uterus. is that right?
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| santaclara
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u r right rida.
thanx.
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| mash
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Peristaltic contractions of the tubes help move the ovum down to the uterus. so, immotile cilia syndrome will not result in ectopic preg.
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| rida
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No problem santaclara.
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| bluestar
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oh? then what will it lead to, mash? :roll:
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| mash
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KS is characterized by the clinical triad of chronic sinusitis, bronchiectasis, and situs inversus.
Males demonstrate infertility secondary to immotile spermatozoa.
here is an interesting article on KS,
http://www.emedicine.com/med/topic1220.htm
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| bluestar
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thank you mash. I was just wondering why there's no named pathology in Kartagener's syn that's related to the defective cilia in oviduct?
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| mash
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Cilia in oviduct beat toward uterus which means the spermatozoa must swim upstream,
Peristaltic contractions and cilia help move the ovum down to the uterus.
though cilia move the egg down the tube to be implanted in the uterus. these aren't necessarily needed, and the egg will often implant normally. Meaning that females are not neccesarily sterile.
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| bluestar
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very good answer. thank you very much, mash! btw, when is your test date?
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| mash
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i m taking it on july 15th n how abt u?
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