igor999
Forum Senior
Topics: 56
Posts: 83
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Does anyone know how Anticoagulants (i.e. warfarin) work in blocking Vitamin K synthesis?
From what I know, it doesn't block the carboxylation reaction directly; rather they block reductases that use Vitamin K epoxide to make Vitamin K hydroquinone. And because Vitamin K hydrquinone (the substrate of gamma-glutamyl carboxylase) is not formed, carboxylation cannot occur.
Do you guys agree?
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