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NBME 6-12
Kaplan Test Prep and Admissions (Kaptest.com)




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Author14 Posts
  #1

He has Cystic Fibrosis but whats going on here?
PLEASE EXPLAIN YOUR ANSWER! Thanks! smiling face

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  #2

Paste the q, Dr.Virgo wink

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"Obstacles are those frightful things you see when you take your EYES off your goal."

  #3

Q 6-12

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  #4

And My answer is D.

it is because Cystic Fibrosis pte can easily dehydrate in hot summer, and that will cause increase of serum osmolarity and posteriorly will increase ADH (vasopressin) secretion leading excess reabsorption of water him in hypotonic situation (low Na).


  #5

OOPS! sorry... I blame the late nights...
Thanks elitokigrin


___________________
Our greatest glory is not in never falling, but in rising every time we fall.

  #6

Sweat Chloride test...

The CFTR in the sweat duct is defective.

Indreased Sweat Chloride.

B?



___________________
Our greatest glory is not in never falling, but in rising every time we fall.

  #7

grin you're welcome~


  #8

Reanalyzing...
The post that I made before it should be for normal person.
In CF they are losing water (ECV), cl- and Na+ as in co transportation in his sweats, which mean sweat electrolytes are increased.
When the option said "excess sweat volume" it sounds like more water loss than electrolyte. As consequence, it will increase serum electrolyte and it will not explain his low sodium and chloride.
So... My last answer is A~
nod


  #9

A

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  #10

When a child or adult with cystic fibrosis sweats excessively in hot weather or because of a fever, dehydration may result because of the increased loss of salt and water. A parent may notice the formation of salt crystals or even a salty taste on the child's skin. (Merck Manual)

In my view: Volume always indicates salt and water loss when u consider the ICF or ECF. The primary problem here is salt and water loss - causing a low Na. Along with Na loss there is water loss so the dehydration and volume depletion.

The distal tubule increase in ADH secretion is a secondary effect of the increased serum osmolarity as a result of dehydration. This would also secondarily contribute to lower serumNa in view of the proximal tubular reabsorption of water and Urine Na < 20 ( pre-renal state).

My answer would be volume loss in this situation.

  #11

A


  #12

B?
His BP also is low
so loss of volume?

  #13

A)

Sweat chloride >60 meq/L absolutely abnormal.

  #14

Which one is right?? A or B
He has CF. His Bp went down and Na & Cl are low.............. I thought A is better because of losing lots of Na&Cl in sweat







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