krsma
Forum Elite
Topics: 40
Posts: 227
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If you add an +NH3 to Uracil which base do you get?
What base do u get if u add +CH3 to Uracil?
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| Bela
Forum Guru
Topics: 76
Posts: 412
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The way I remember it is:
C-->U-->T
If you add a CH3 to uracil, you get Thymine, which is a methylated Uracil.
If you add a NH3 to uracil, you move the opposite direction (to the left) and will get Cytosine.
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La vita e bella!
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| asmi
Forum Hero
Topics: 1043
Posts: 4,609
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yes,
Now let us link this with pharma..
:arrow: Resistance to Cytosinearabinoside related to increase in deaminase enzyme .converting it into uracil arabinoside.
:arrow: methotrexate is also one example...where by inhibiting DHFR it prevents conversion of dUMP--->dTMP( i.e uracil to thymine)
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| usmleasr
Forum Guru
Topics: 105
Posts: 970
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good link asmi 
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| krsma
Forum Elite
Topics: 40
Posts: 227
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correct guys, and good job asmi :icon_thumb:
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| usmle prep
Forum Senior
Topics: 21
Posts: 100
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:idea: THANKS !!BELA & ASMI!!!
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