dallas
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please could u guys point out the correct answer
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| new_n_lost
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Choice C IL 2 Induces NK cells Activity.
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| new_n_lost
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It causes T- Cell Proliferaton with Activation of Helper T cells , NK cells and LAK Cells
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| dallas
Forum Junior
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nnl, correct me if I am wrong bec as it is my basics are not very good but I was under the impression that IL 2 also activates CTLs . would that make the second option also right?
thanks....
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| new_n_lost
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IL-2 activates the cytotoxic (CD8) cells and in effect also NK cells...but because we are talking about tumor cells, it is better to pick NK cells because they are SPECIFIC for tumor infected cells
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| new_n_lost
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NK Cells r more Effective in the Tumor Suppression rather than CD 8 cells. Though u r essentially right, I also was abt to opt B but when i saw NK Cells i said Yup thats the one i m looking for.
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| dallas
Forum Junior
Topics: 10
Posts: 43
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ok thanks a lot for clearing it up for me
appreciate it a lot....
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| rishta
Forum Newbie
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C-nk calls are enhanced by IL-2(others r IFN-alpha and IFN-beta)
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| kingusmle
Forum Elite
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c agree...il2 itself cant say is cytotoxic...coz it also stimulates B cells
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| spider
Forum Newbie
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B.. It is CTL activity due to Il2 therapy. Tumor cells is full of Class1. NK does not kill when classI is around.
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| sfk
Forum Elite
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i think ans is B. IL2 activates CTL's.
Although NK cells are more imp in tumour surveillance, the question mentions use of IL-2, which, as far as i know does not activate the NK cells, They are activated by IL12 & IFN-gamma.
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| antidepressant
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new_n_lost wrote:
IL-2 activates the cytotoxic (CD8) cells and in effect also NK cells...but because we are talking about tumor cells, it is better to pick NK cells because they are SPECIFIC for tumor infected cells
I chose B too, but it make sense, good point.
anyone has anything to say against or for B?
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| tia
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C 
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| antidepressant
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oh, i found in kaplan pharma just now ( page 316) 2006-07, Aldesleukin ( IL-2) : increases Lymphocyte differentiation and increase NK, used in renal cell cancer and metastatic melanoma, why its not mentioned in immunology then, in immunology section it only mentioned that IFN-gamma and IL-12 activate NK.
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| antidepressant
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you are good. did you do this nbme, tia?
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