26) The 18-year-old son of an Arab Sheik is flown to a hospital in the United States after his local doctor discovers an abdominal mass. The young man had a two year history of weight loss accompanied by production of malodorous stool with excessive flatulence. Duodenal biopsy with histopathologic examination demonstrates villous atrophy and massive infiltration of the lamina propria by lymphocytes, plasma cells, and immunoblasts that do not morphologically appear overtly malignant. Biopsy of a mesenteric lymph node shows node replacement by a similar infiltrate. Which of the following is the most likely diagnosis?
A. Heavy chain disease B. Macroglobulinemia C. Monoclonal gammopathy of undetermined significance D. Multiple myeloma E. Myelodysplastic syndrome
sprint123 Forum Guru
Topics: 129 Posts: 870
08/05/07 - 07:39 AM
#2
Macroglobuliemia
cirus Forum Guru
Topics: 108 Posts: 740
08/05/07 - 07:57 AM
#3
, think again, its not easy
nagi_step1 Forum Newbie
Topics: 3 Posts: 31
08/05/07 - 09:33 PM
#4
A) HEAVY CHAIN DISEASE IgA
Justice Forum Fanatic
Topics: 117 Posts: 2,324
08/05/07 - 11:54 PM
#5
E. Myelodysplastic syndrome More than one cell lineage is involved ___________________ Don't live in a town where there are no doctors
cirus Forum Guru
Topics: 108 Posts: 740
08/06/07 - 01:44 AM
#6
nagi_step1 wrote: A) HEAVY CHAIN DISEASE IgA
, yep this is Heavy chain D
Its an IgA disease ( increased level of IgA) + Abdominal & mesenteric LNs +/- Hepatomegaly
, think again, its not easy
, yep this is Heavy chain D