asmi
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what is the importance of major and minor grooves in dsDNA molecule ?
Name the drugs which acts here ?
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| kris2c
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:idea: What is the importance of major and minor grooves in dsDNA molecule ?
The grooves of DNA are the BINGING SITES (like receptors) for many drugs and proteins who interact with DNA. These proteins will allow the cell to express different genes that they may have.
:idea: Name the drugs which acts here ?
Drugs that belong to the family of NETROPSINS bind to the minor groove of DNA present in the cancer cells, thus knoking out the function of DNA in cancer cells, so the cancer cells will not be able to proliferate.
](*,) Is that correct asmi?
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Kris2c
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| kris2c
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it's "BINDING SITE"
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Kris2c
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| usmleasr
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:roll:
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| asmi
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you are right kris ,
They are binding sites for regulatory proteins/DNA binding proteins.
:arrow: Dactinomycin ( actinomycin D) exert cytotoxic effect by intercalating into minor./major groove....thus interfering with DNA and RNA synthesis .
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